Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 100-88-9
Drug Levels and Effects
Summary of Use during Lactation
Very little cyclamate enters breastmilk after maternal ingestion. However, some authors suggest that women may wish to limit the consumption of nonnutritive sweeteners while breastfeeding because their effect on the nursing infants are unknown.[1,2]
Drug Levels
Maternal Levels. Forty-nine women consumed a beverage containing 60 mg of cyclamate. Normal and overweight women were about equally represented in the sample. Breastmilk samples were collected before the beverage and at 30, 60, 120, 180, 240, 300, and 360 minutes after the beverage. The average peak milk concentration was 2.56 mcg/L an occurred at 5 hours after the beverage.[3]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
- Sylvetsky AC, Gardner AL, Bauman V, et al. Nonnutritive sweeteners in breast milk. J Toxicol Environ Health A. 2015;78:1029–32. [PMC free article: PMC5583633] [PubMed: 26267522]
- 2.
- Rother KI, Sylvetsky AC, Schiffman SS. Non-nutritive sweeteners in breast milk: Perspective on potential implications of recent findings. Arch Toxicol. 2015;89:2169–71. [PMC free article: PMC4749460] [PubMed: 26462668]
- 3.
- Stampe S, Leth-Møller M, Greibe E, et al. Artificial sweeteners in breast milk: A clinical investigation with a kinetic perspective. Nutrients. 2022;14:2635. [PMC free article: PMC9268461] [PubMed: 35807817]
Substance Identification
Substance Name
Cyclamate
CAS Registry Number
100-88-9
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PMCPubMed Central citations
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- Review Acesulfame.[Drugs and Lactation Database (...]Review Acesulfame.. Drugs and Lactation Database (LactMed®). 2006
- Review Sucralose.[Drugs and Lactation Database (...]Review Sucralose.. Drugs and Lactation Database (LactMed®). 2006
- Review Saccharin.[Drugs and Lactation Database (...]Review Saccharin.. Drugs and Lactation Database (LactMed®). 2006
- Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates.[Acta Crystallogr B. 2007]Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates.Leban I, Rudan-Tasic D, Lah N, Klofutar C. Acta Crystallogr B. 2007 Jun; 63(Pt 3):418-25. Epub 2007 May 16.
- The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers.[Toxicol Appl Pharmacol. 1992]The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers.Buss NE, Renwick AG, Donaldson KM, George CF. Toxicol Appl Pharmacol. 1992 Aug; 115(2):199-210.
- Cyclamate - Drugs and Lactation Database (LactMed®)Cyclamate - Drugs and Lactation Database (LactMed®)
Your browsing activity is empty.
Activity recording is turned off.
See more...