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Shorter Versus Longer Durations of Any Human Milk Feeding and Food Allergies, Allergic Rhinitis, Atopic Dermatitis, and Asthma: A Systematic Review

Authors

, MS,a , PhD,a , MPH,a ,a , MLS,b , MLS, MPH,c , MD,d , PhD, RD,e , MS, RD,f , MD, PhD,g , PhD, RD, IBCLC,h , PhD,i , MD, MPH,j , PhD,k , MD,l , PhD, RD,m , MS, RDN,n and , PhDn.

Affiliations

a Systematic review analyst, Nutrition Evidence Systematic Review (NESR) team; Panum Group under contract with the Food and Nutrition Service (FNS), U.S. Department of Agriculture (USDA)
b Biomedical librarian, NESR team; National Institutes of Health Library, U.S. Department of Health and Human Services (HHS)
c Systematic review librarian, NESR team; Office of Nutrition Guidance and Analysis (ONGA), Center for Nutrition Policy and Promotion (CNPP), FNS, USDA
d Member, Infant Milk-Feeding Practices Technical Expert Collaborative, Pregnancy and Birth to 24 Months Project; Dell Medical School at the University of Texas at Austin
e Member and Federal Expert Group Liaison, Infant Milk-Feeding Practices Technical Expert Collaborative, Pregnancy and Birth to 24 Months Project; U.S. Food and Drug Administration
f Federal Expert Group Liaison, Infant Milk-Feeding Practices Technical Expert Collaborative, Pregnancy and Birth to 24 Months Project; U.S. Food and Drug Administration
g Member, Infant Milk-Feeding Practices Technical Expert Collaborative, Pregnancy and Birth to 24 Months Project; University of Rochester Medical Center
h Member, Infant Milk-Feeding Practices Technical Expert Collaborative, Pregnancy and Birth to 24 Months Project; University of Cincinnati College of Allied Health Sciences
i Member, Infant Milk-Feeding Practices Technical Expert Collaborative, Pregnancy and Birth to 24 Months Project; Division of Nutritional Sciences, Cornell University
j Member, Infant Milk-Feeding Practices Technical Expert Collaborative, Pregnancy and Birth to 24 Months Project; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Department of Nutrition, Harvard School of Public Health
k Member, Infant Milk-Feeding Practices Technical Expert Collaborative, Pregnancy and Birth to 24 Months Project; Department of Social and Behavioral Sciences, Yale School of Public Health
l Member, Infant Milk-Feeding Practices Technical Expert Collaborative, Pregnancy and Birth to 24 Months Project; University of Iowa
m Project Lead, Pregnancy and Birth to 24 Months Project; Office of Disease Prevention and Health Promotion, HHS
n Project Lead, Pregnancy and Birth to 24 Months Project; NESR team, ONGA, CNPP, FNS, USDA
Alexandria (VA): USDA Nutrition Evidence Systematic Review; .

TECHNICAL ABSTRACT

Background

  • This systematic review was conducted as part of the U.S. Department of Agriculture and Department of Health and Human Services Pregnancy and Birth to 24 Months Project.
  • The goal of this systematic review was to examine the following question: What is the relationship between shorter versus longer durations of any human milk feeding and food allergies, allergic rhinitis, atopic dermatitis, and asthma?
  • This systematic review examines comparisons of infants who were fed human milk for shorter durations with infants who were fed human milk for longer durations. Human milk feeding was defined as feeding human milk alone or in combination with infant formula and/or complementary foods or beverages such as cow’s milk. Human milk was defined as mother’s own milk provided at the breast (i.e., nursing) or expressed and fed fresh or after refrigeration or freezing. Donor milk (e.g., banked milk) was not examined in this review.
  • This systematic review examines available evidence related to food allergies, allergic rhinitis, and atopic dermatitis from birth through adulthood and asthma from childhood through adulthood (outcomes prior to childhood may represent transient recurrent wheeze4).

Conclusion statement and grade

  • Moderate evidence mostly from observational studies suggests that, among infants fed human milk, shorter versus longer durations of any human milk feeding are associated with higher risk of asthma in childhood and adolescence.
    Limited evidence does not suggest a relationship between the duration of any human milk feeding and allergic rhinitis or atopic dermatitis in childhood.
    Evidence about the relationship between shorter versus longer durations of any human milk feeding and atopic dermatitis from birth to 24 months is inconclusive, and there is insufficient evidence to determine the relationship of shorter versus longer durations of any human milk feeding with food allergies throughout the lifespan; allergic rhinitis from birth to 24 months, in adolescence, or in adulthood; asthma in adulthood; and atopic dermatitis in adolescence or in adulthood.
    Grade: Moderate – asthma in childhood and adolescence; Limited – allergic rhinitis and atopic dermatitis in childhood; Grade Not Assignable – food allergies throughout the lifespan, allergic rhinitis and atopic dermatitis outside of childhood, asthma in adulthood

Methods

  • The systematic review was conducted by a team of staff from the Nutrition Evidence Systematic Review in collaboration with a Technical Expert Collaborative.
  • A single literature search was conducted to identify literature for several related systematic reviews that examined infant milk-feeding practices and different outcomes. The search was conducted in CINAHL, Cochrane, Embase, and PubMed, and used a search date range of January 1980 to March 2016. A manual search was done to identify articles that may not have been included in the electronic databases searched.
  • Articles were screened independently by 2 NESR analysts to determine which articles met predetermined criteria for inclusion.
  • Data from each included article were extracted, risks of bias were assessed, and both were checked for accuracy.
  • The body of evidence was qualitatively synthesized, a conclusion statement was developed, and the strength of the evidence (grade) was assessed using pre-established criteria including evaluation of the internal validity/risk of bias, adequacy, consistency, impact, and generalizability of available evidence.

Summary of evidence

  • Thirty-five articles met the inclusion criteria for this systematic review, including 3 with evidence about food allergies, 7 with evidence about allergic rhinitis, 15 with evidence about atopic dermatitis, and 23 with evidence about asthma. Almost all of the evidence was from observational studies.
  • Evidence about the association between shorter versus longer durations of any human milk feeding and higher risk of asthma in childhood and adolescence was moderate. Across the 20 independent studies (21 articles), 8 found statistically significant associations and, with 1 exception, they showed that shorter durations of any human milk feeding was associated with higher risk. The majority of nonsignificant associations were also consistent in suggesting higher risk of asthma in childhood and adolescence with shorter durations of any human milk feeding, and some of the inconsistency in statistical significance may be explained by insufficient statistical power. The ability to draw stronger conclusions was primarily limited by the limited statistical power in some studies and concerns about reverse causality and internal validity, such as the potential for confounding in a body of evidence primarily made up of observational studies.
  • Evidence about the lack of an association between shorter versus longer durations of any human milk feeding and allergic rhinitis and atopic dermatitis in childhood was limited. Across the 5 independent studies (6 articles) that examined allergic rhinitis in children, the only significant association was from a subsample analysis of African-American children, and there were no comparable analyses with which to compare the result. Likewise, across the 8 independent studies (9 articles) that examined atopic dermatitis in children, the only significant associations were reported by a study with risk of multiple comparison bias. The ability to draw stronger conclusions was primarily limited by the small number of studies, limited statistical power in some studies, concerns with generalizability of the samples to diverse U.S. populations, and concern about the potential for confounding.
  • Evidence about atopic dermatitis from birth to 24 months was inconclusive. Across 8 studies, the associations were inconsistent in direction. There was also concern about the specificity of diagnosing atopic dermatitis in this age group.
  • Evidence related to food allergies throughout the lifespan, and outcomes beyond childhood, in general, was scant.
4

Stein RT, Holberg CJ, Morgan WJ, Wright AL, Lombardi E, Taussig L, Martinez FD. Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood. Thorax 1997;52(11):946–52. [PMC free article: PMC1758449] [PubMed: 9487341]

Funding source: United States Department of Agriculture, Food and Nutrition Service, Center for Nutrition Policy and Promotion, Alexandria, VA

Suggested citation:

Güngör D, Nadaud P, Dreibelbis C, LaPergola C, Terry N, Wong YP, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Nommsen-Rivers LA, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler, EE, Casavale KO, Spahn JM, Stoody E. Shorter Versus Longer Durations of Any Human Milk Feeding and Food Allergies, Allergic Rhinitis, Atopic Dermatitis, and Asthma: A Systematic Review. April 2019. U.S. Department of Agriculture, Food and Nutrition Service, Center for Nutrition Policy and Promotion, Nutrition Evidence Systematic Review. Available at: https://doi.org/10.52570/NESR.PB242018.SR0206

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Related citations:

This systematic review has also been published in the American Journal of Clinical Nutrition: Güngör D, Nadaud P, LaPergola C, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Nommsen-Rivers LA, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler, EE, Spahn JM. Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: A systematic review. Am J Clin Nutr. 2019;109(7):772S-799S. Available at: https://doi.org/10.1093/ajcn/nqy283 [PMC free article: PMC6500928] [PubMed: 30982870]

Related citations are published in the American Journal of Clinical Nutrition:

  • P/B-24 Project overview: Stoody EE, Spahn JM, Casavale KO. The Pregnancy and Birth to 24 Months Project: a series of systematic reviews on diet and health. Am J Clin Nutr. 2019;109(7):685S–97S. Available at: https://doi.org/10.1093/ajcn/nqy372 [PubMed: 30982878].
  • P/B-24 Project systematic review methodology: Obbagy JE, Spahn JM, Wong YP, Psota TL, Spill MK, Dreibelbis C, Gungor DE, Nadaud P, Raghavan R, Callahan EH, English LK, Kingshipp BL, LaPergola CC, Shapiro MJ, Stoody EE. Systematic review methodols used in the Pregnancy and Birth to 24 Months Project. Am J Clin Nutr. 2019;109(7):698S–704S. Available at https://doi.org/10.1093/ajcn/nqy226 [PubMed: 30445449].

Copyright Notice

The contents of this document may be used and reprinted without permission. Endorsements by NESR, NGAD, CNPP, FNS, or USDA of derivative products developed from this work may not be stated or implied.

Bookshelf ID: NBK580361PMID: 35593772DOI: 10.52570/NESR.PB242018.SR0206