U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Cover of Dietary Patterns before and during Pregnancy and Gestational Age- and Sex-Specific Birth Weight: A Systematic Review

Dietary Patterns before and during Pregnancy and Gestational Age- and Sex-Specific Birth Weight: A Systematic Review

, DrPH, MPH, MSc, , MPH, , PhD, , MLS, MPH, , MLS, , DrPH, RD, , MS, RD, , PhD, MPH, RD, , PhD, MPH, RD, , ScD, RD, , PhD, , PhD, MPH, RDN, , PhD, RD, , MS, RDN, and , PhD.

Author Information and Affiliations
Alexandria (VA): USDA Nutrition Evidence Systematic Review; .

TECHNICAL ABSTRACT

Background

  • This systematic review was conducted as part of the U.S. Department of Agriculture and Department of Health and Human Services Pregnancy and Birth to 24 Months Project.
  • The goal of this systematic review was to examine the following question: what is the relationship between dietary patterns before and during pregnancy and gestational age- and sex-specific birth weight.

Conclusion Statement and Grades

  • No conclusion can be drawn on the association between dietary patterns during pregnancy and birth weight outcomes. Although research is available, the ability to draw a conclusion is restricted by
    • inconsistency in study findings,
    • inadequate adjustment of birth weight for gestational age and sex, and
    • variation in study design, dietary assessment methodology, and adjustment of key confounding factors.
    Grade: Grade not assignable
  • Insufficient evidence exists to estimate the association between dietary patterns before pregnancy and birth weight outcomes. There are not enough studies available to answer this question.
    Grade: Grade not assignable

Methods

  • The systematic review was conducted by a team of staff from the Nutrition Evidence Systematic Review in collaboration with a Technical Expert Collaborative.
  • Literature searches were conducted using PubMed, Embase, Cochrane, and other databases to identify studies that evaluated the relationship between dietary patterns before and during pregnancy and gestational age- and sex-specific birth weight. A manual search was conducted to identify articles that may not have been included in the electronic databases searched. Articles were screened by two authors independently for inclusion based on pre-determined criteria.
  • Data from each included article were extracted, risks of bias were assessed, and both were checked for accuracy. The body of evidence was qualitatively synthesized, a conclusion statement was developed, and the strength of the evidence (grade) was assessed using pre-established criteria including evaluation of the internal validity/risk of bias, adequacy, consistency, impact, and generalizability of available evidence.

Summary of Evidence

  • This systematic review includes18 prospective cohort, 1 retrospective cohort and 2 randomized control trials published between 1986 and 2016.
  • The studies used multiple approaches to assess dietary patterns:
    • Nine studies used an index/score to assess dietary patterns.
    • Eight studies used factor/principal component analysis (PCA).
    • Two randomized controlled trials assigned subjects to one of two experimental diets.
    • One study did not use a formal method to arrive at a dietary pattern.
    • One study used both logistic regression and PCA.
  • Many studies did not standardize for gestational age and/or infant sex when assessing birth weight.
    • Just one-third of studies (n=7) used both gestational age- and sex - specific cut-off values when defining small for gestational age (SGA), large for gestational age (LGA), appropriate for gestational age (AGA), or intrauterine growth restriction (IUGR).
    • Nine out of 21 studies reported birth weight, alone, without standardizing for gestational age or sex using z-scores.
  • Study findings were highly inconsistent across the body of evidence. About half of studies (n=10) found no association between dietary patterns and birth weight outcomes. Among studies that observed an association, there was limited consistency in direction of effect and the dietary patterns generated.
  • There are serious limitations to the generalizability of this review. Minority, lower-SES, and adolescent populations are underrepresented in the body of evidence.
  • The ability to draw strong conclusions was limited by the following issues:
    • There was a lack of consistency in study findings.
    • The data were primarily observational in nature, making it difficult to determine causal effect of the dietary patterns.
    • Many studies did not adjust birth weight for gestational age and sex, and there was heterogeneity among the standardized measures that were used.
    • The timing of exposure assessment and the duration of recall periods varied across studies.
    • Key confounding factors were not consistently accounted for.
    • None of the studies assessed effect measure modification between dietary patterns and maternal pre-pregnancy BMI in the context of birth weight outcomes.
    • Many studies were conducted outside of the U.S.
    • Adolescent, minority, and lower-SES populations were underrepresented.
  • Additional research is needed that should:
    • Include diverse populations from the U.S. and elsewhere with varying age groups (including adolescents) and different racial/ethnic and socioeconomic backgrounds.
    • Assess effect measure modification by pre-pregnancy BMI and gestational weight gain.
    • Use a standardized birth size measure (such as one developed by the INTERGROWTH-21st project) that would enable valid comparisons between and within countries1.
    • Include well-designed and sufficiently powered RCTs.
    • Foster collaborative efforts across different regions and populations so that dietary patterns can be more consistently scored, compared and reproduced across studies.
    • Develop and validate novel epidemiological tools that can accurately capture the complexity of dietary habits.
    • Promote harmonization of research methods across various cohorts and randomized trials, similar to the National Cancer Institute’s Dietary Patterns Methods Project2.
    • Adjust for key confounding factors in observational studies, including parity, educational attainment, smoking status, race/ethnicity, maternal age, family poverty income ratio, pre-pregnancy BMI, mean total energy intake and gestational weight gain.
1

Westerway, S. C., Papageorghiou, A. T., Hirst, J., Costa, F. D., Hyett, J., & Walker, S. P. (2015). INTERGROWTH-21st - Time to standardise fetal measurement in Australia. Australas J Ultrasound Med, 18(3), 91–95. doi:10.1002/j.2205-0140.2015.tb00206.x [PMC free article: PMC5024962] [PubMed: 28191248] [CrossRef]

2

Liese, A. D., Krebs-Smith, S. M., Subar, A. F., George, S. M., Harmon, B. E., Neuhouser, M. L., … Reedy, J. (2015). The Dietary Patterns Methods Project: synthesis of findings across cohorts and relevance to dietary guidance. J Nutr, 145(3), 393–402. doi:10.3945/jn.114.205336 [PMC free article: PMC4336525] [PubMed: 25733454] [CrossRef]

FUNDING SOURCE: United States Department of Agriculture, Food and Nutrition Service, Center for Nutrition Policy and Promotion, Alexandria, VA

Suggested citation:

Raghavan R, Dreibelbis C, Kingshipp BJ, Wong, YP, Terry N, Abrams B, Bartholomew A, Bodnar LM, Gernand A, Rasmussen K, Siega-Riz AM, Stang JS, Casavale KO, Spahn JM, Stoody E. Dietary Patterns before and during Pregnancy and Gestational Age- and Sex-Specific Birth Weight: A Systematic Review. April 2019. U.S. Department of Agriculture, Food and Nutrition Service, Center for Nutrition Policy and Promotion, Nutrition Evidence Systematic Review. Available at: https://doi.org/10.52570/NESR.PB242018.SR0104

In accordance with Federal civil rights law and U.S. Department of Agriculture (USDA) civil rights regulations and policies, the USDA, its Agencies, offices, and employees, and institutions participating in or administering USDA programs are prohibited from discriminating based on race, color, national origin, religion, sex, gender identity (including gender expression), sexual orientation, disability, age, marital status, family/parental status, income derived from a public assistance program, political beliefs, or reprisal or retaliation for prior civil rights activity, in any program or activity conducted or funded by USDA (not all bases apply to all programs). Remedies and complaint filing deadlines vary by program or incident.

Persons using assistive technology should be able to access information in this report. For further assistance please email vog.ADSU@RSEN.NF.MS.

Persons with disabilities who require alternative means of communication for program information (e.g., Braille, large print, audiotape, American Sign Language, etc.) should contact the responsible Agency or USDA’s TARGET Center at (202) 720-2600 (voice and TTY) or contact USDA through the Federal Relay Service at (800) 877-8339. Additionally, program information may be made available in languages other than English.

To file a program discrimination complaint, complete the USDA Program Discrimination Complaint Form, AD-3027, found online at How to File a Program Discrimination Complaint and at any USDA office or write a letter addressed to USDA and provide in the letter all of the information requested in the form. To request a copy of the complaint form, call (866) 632-9992. Submit your completed form or letter to USDA by:

(1)

mail: U.S. Department of Agriculture, Office of the Assistant Secretary for Civil Rights, 1400 Independence Avenue, SW, Washington, D.C. 20250-9410;

(2)

fax: (202) 690-7442; or

(3)

email: vog.adsu@ekatni.margorp.

USDA is an equal opportunity provider, employer, and lender.

Related citations:

This systematic review has also been published in the American Journal of Clinical Nutrition: Raghavan R, Dreibelbis C, Kingshipp BL, Wong YP, Abrams B, Gernand AD, et al. Dietary patterns before and during pregnancy and birth outcomes: a systematic review. Am J Clin Nutr. 2019;109(7):729S–56S. Available at: https://doi.org/10.1093/ajcn/nqy353 [PubMed: 30982873].

Related citations are published in the American Journal of Clinical Nutrition:

  • P/B-24 Project overview: Stoody EE, Spahn JM, Casavale KO. The Pregnancy and Birth to 24 Months Project: a series of systematic reviews on diet and health. Am J Clin Nutr. 2019;109(7):685S–97S. Available at: https://doi.org/10.1093/ajcn/nqy372 [PubMed: 30982878].
  • P/B-24 Project systematic review methodology: Obbagy JE, Spahn JM, Wong YP, Psota TL, Spill MK, Dreibelbis C, Gungor DE, Nadaud P, Raghavan R, Callahan EH, English LK, Kingshipp BL, LaPergola CC, Shapiro MJ, Stoody EE. Systematic review methodols used in the Pregnancy and Birth to 24 Months Project. Am J Clin Nutr. 2019;109(7):698S–704S. Available at https://doi.org/10.1093/ajcn/nqy226 [PubMed: 30445449].

Copyright Notice

The contents of this document may be used and reprinted without permission. Endorsements by NESR, NGAD, CNPP, FNS, or USDA of derivative products developed from this work may not be stated or implied.

Bookshelf ID: NBK580175PMID: 35544663DOI: 10.52570/NESR.PB242018.SR0104

Views

  • PubReader
  • Print View
  • Cite this Page
  • PDF version of this title (1.7M)

Other titles in this collection

Related information

Similar articles in PubMed

See reviews...See all...

Recent Activity

ClearTurn OffTurn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...