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Varki A, Cummings RD, Esko JD, et al., editors. Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. doi: 10.1101/glycobiology.4e.12
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General structure of glycosylphosphatidylinositol (GPI) anchors attached to proteins. All characterized GPI anchors share a common core consisting of ethanolamine-PO4-6Manα1-2Manα1-6Manα1-4GlcNα1-6myo-inositol-1-PO4-lipid. Heterogeneity in GPI anchors is derived from various substitutions of this core structure and is represented here as R groups (see Online Appendix 12B). In mammalian cells, ethanolamine-PO4 on α1-6linked Man (Man-2) rather than α1-2linked Man (Man-3) is preferentially used to attach GPI to some GPI-anchored proteins. (Adapted, with permission, from Cole RN, Hart GW. 1997. In Glycoproteins II [ed. Montreuil J, et al.], pp. 69–88. Elsevier, Amsterdam, © Elsevier.)
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From: Chapter 12, Glycosylphosphatidylinositol Anchors
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