An official website of the United States government
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Varki A, Cummings RD, Esko JD, et al., editors. Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. doi: 10.1101/glycobiology.4e.45
Congenital disorders of glycosylation in the N-glycosylation pathway. The figure shows individual steps in lipid-linked oligosaccharide (LLO) biosynthesis, glycan transfer to protein, and N-glycan processing similar to Figure 9.3 and Figure 9.4. The shuttling of the glycosylation machinery between the endoplasmic reticulum (ER) and Golgi and within the Golgi is organized and regulated by cytoplasmic complexes including the conserved oligomeric Golgi (COG) complex (see Figure 45.4 for Golgi homeostasis defects). Red gene names indicate CDGs. MAN1B1 shown in the ER is now known to act in the GOLGI as well.
Download Teaching Slide (PPTX, 12M)
From: Chapter 45, Congenital Disorders of Glycosylation
The content of this book is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported license. To view the terms and conditions of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
Your browsing activity is empty.
Activity recording is turned off.
See more...
