FIGURE 17.1.. Proteoglycans consist of a protein core (brown) and one or more covalently attached glycosaminoglycan chains (dark blue, HS, heparan sulfate; yellow, CS/DS, chondroitin sulfate/dermatan sulfate; light blue, KS, keratan sulfate).

FIGURE 17.1.

Proteoglycans consist of a protein core (brown) and one or more covalently attached glycosaminoglycan chains (dark blue, HS, heparan sulfate; yellow, CS/DS, chondroitin sulfate/dermatan sulfate; light blue, KS, keratan sulfate). Membrane proteoglycans either span the plasma membrane (type I membrane proteins) or are linked by a glycosylphosphatidylinositol (GPI) anchor. Extracellular matrix proteoglycans are usually secreted, but some proteoglycans can be proteolytically cleaved and shed from the cell surface (not shown).

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From: Chapter 17, Proteoglycans and Sulfated Glycosaminoglycans

Cover of Essentials of Glycobiology
Essentials of Glycobiology [Internet]. 4th edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022.
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