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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 84929-41-9; 94-62-2
Drug Levels and Effects
Summary of Use during Lactation
Black pepper (Piper nigrum) contains piperine, which is the main pungent component. Piperine is often incorporated into turmeric products because it enhances the oral bioavailability of curcumin. Piperine can be found in breastmilk after maternal ingestion, but the piperine levels appear to be far below the taste threshold after ingestion of typical dietary amounts of pepper.[1] No studies have been performed with ingestion of piperine-containing pharmaceutical products.
Drug Levels
Maternal Levels. Thirteen nursing mothers who were nursing their infants were served a curry dish that contained an average piperine concentration of 264 nmol/gram (75 mcg/gram) of the curry sause. The peak piperine concentration in milk of 31.2 nM (8.9 mcg/L) occurred at 1 hour after the meal in these mothers with a low basal piperine concentration in milk. The authors assumed that the concentration of piperine was too low for conscious detection by the nursing infant, but that it could contribute to a sensory desensitization toward pungency in later life.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- N'Diaye K, Debong M, Behr J, et al. Dietary piperine is transferred Into the milk of nursing mothers. Mol Nutr Food Res. 2021;65:2100508. [PubMed: 34633734]
Substance Identification
Substance Name
Black Pepper
Scientific Name
Piper nigrum
CAS Registry Number
84929-41-9
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Determination and risk characterisation of bio-active piperine in black pepper and selected food containing black pepper consumed in Korea.[Food Sci Biotechnol. 2021]Determination and risk characterisation of bio-active piperine in black pepper and selected food containing black pepper consumed in Korea.Lee JG, Kim AY, Kim DW, Kim YJ. Food Sci Biotechnol. 2021 Feb; 30(2):209-215. Epub 2021 Feb 6.
- Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.).[BMC Genomics. 2021]Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.).Ding Y, Mao Y, Cen Y, Hu L, Su Y, Ma X, Long L, Hu H, Hao C, Luo J. BMC Genomics. 2021 Nov 19; 22(1):838. Epub 2021 Nov 19.
- Review Black pepper and its pungent principle-piperine: a review of diverse physiological effects.[Crit Rev Food Sci Nutr. 2007]Review Black pepper and its pungent principle-piperine: a review of diverse physiological effects.Srinivasan K. Crit Rev Food Sci Nutr. 2007; 47(8):735-48.
- The terminal enzymatic step in piperine biosynthesis is co-localized with the product piperine in specialized cells of black pepper (Piper nigrum L.).[Plant J. 2022]The terminal enzymatic step in piperine biosynthesis is co-localized with the product piperine in specialized cells of black pepper (Piper nigrum L.).Jäckel L, Schnabel A, Stellmach H, Klauß U, Matschi S, Hause G, Vogt T. Plant J. 2022 Aug; 111(3):731-747. Epub 2022 Jun 20.
- Review Turmeric.[Drugs and Lactation Database (...]Review Turmeric.. Drugs and Lactation Database (LactMed®). 2006
- Black Pepper - Drugs and Lactation Database (LactMed®)Black Pepper - Drugs and Lactation Database (LactMed®)
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