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Roberts I, Shakur-Still H, Afolabi A, et al. A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT. Southampton (UK): NIHR Journals Library; 2021 Oct. (Health Technology Assessment, No. 25.58.)

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A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT.

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Appendix 1HALT-IT trial organisation

Trial Steering Committee

Christopher Hawkey (chairperson), Adefemi Afolabi, Jack Cuzick, Kenneth Halligan (patient representative), David Henry, Chris Metcalfe and Ian Roberts.

Data Monitoring and Ethics Committee

Richard Gray (chairperson), Alan Barkun, Suresh David, Philip Devereaux and Tony Brady (independent statistician).

Protocol Committee

Ian Roberts, Haleema Shakur-Still, Timothy Coats, Phil Edwards, Ian Gilmore, Vipul Jairath, Katharine Ker, Daniela Manno, Simon Stanworth and Andrew Veitch.

Trial Co-ordinating Centre Team

Clinical Trials Unit

Monica Arribas (trial manager/research assistant), Emma Austin (assistant trial manager), Kiran Bal (assistant trial manager), Eni Balogun (trial manager), Collette Barrow (trial administrator), Danielle Beaumont (senior trial manager/research fellow), Myriam Benyahia (CTU administrator), Amy Brenner (research fellow), Imogen Brooks (trial assistant 2016–18), Madeleine Cargill (data assistant), Laura Carrington (trial administrator), Phil Edwards (statistician 2012–16), Lauren Frimley (trial manager/research assistant), Amber Geer (assistant data manager), Daniel Gilbert (data assistant 2012–13), Catherine Gilliam (trial administrator), Julio Gil Onandia (clerical assistant), Nayia Golfi (trial manager 2013–15), Daniel Hetherington (trial assistant 2012–15), Courtenay Howe (CTU administrator 2015–17), Carolyn Hughes (data assistant 2016–17), David I’anson (assistant trial manager 2016–17), Rob Jackson (data manager 2012–15), Miland Joshi (statistician 2016–17), Sneha Kansagra (assistant trial manager 2016–18), Taemi Kawahara (senior trial manager 2012–15), Katharine Ker (lecturer), Sergey Kostrov (systems officer 2015–19), Daniela Manno (clinical lecturer 2012–15), Raoul Mansukhani (medical statistician 2019–20), Hakim Miah (IT systems manager 2013–19), Bernard Ndungu (assistant trial manager 2016–17), Kelly Needham (statistician 2018–20), Aroudra Outtandy (trial assistant 2013–15), Daniel Pearson (data assistant 2018–19), Tracey Pepple (acting senior data manager 2014–19), Danielle Prowse (assistant data manager), Nigel Quashi (data manager 2013–16), Anna Quinn (data assistant 2013–15), Maria Ramos (senior project administrator 2012–15), Laura Ranopa (trial assistant 2015–20), Mia Reid (clerical assistant 2016–18), Ian Roberts (chief investigator/CTU co-director), Chris Roukas (trial administrator 2013–15), Haleema Shakur-Still (project director/CTU co-director), Chelci Squires (trial assistant 2014–16), Jemma Tanner (clinical trials associate 2013–16), Andrew Thayne (data assistant) and Ruhama Uddin (trial assistant 2018–19).

Rawalpindi Medical University Pakistan National Co-ordinating Centre Team

Rizwana Chaudhri (co-ordinating centre director), Muttiullah Mutti (clinical lead), Kiran Javaid (assistant research co-ordinator) and Aasia Kayani (research co-ordinator).

Nigeria Co-ordinating Team, University College Hospital Ibadan

Bukola Fawole (co-ordinating centre director), Folasade Adenike Bello (co-ordinating centre director), Oladapo Olayemi (co-ordinating centre director), Adefemi Afolabi (national principal investigator), Olujide Okunade (assistant trial co-ordinator) and Olusade Adetayo (assistant trial co-ordinator).

National Co-ordinators

Rizwana Chaudhri (Pakistan), Muttiullah Mutti (Pakistan), Adefemi Afolabi (Nigeria), Folasade Adenike Bello (Nigeria), Bukola Fawole (Nigeria), Oladapo Olayemi (Nigeria), Hussein Khamis (Egypt), Mohammad Shukri Bin Jahit (Malaysia), Tamar Gogichaishvili (Georgia), Radu Bogdan Mateescu (Romania), Ajay Adhikaree (Nepal), Abdelmounem Eltayeib Abdo (Sudan), Mohammad Zaher (Saudi Arabia), Conor Deasy (Ireland), Joaquin Alvarez Gregori (Spain), Bobby Wellsh (Papua New Guinea) and Luke Lawton (Australia).

HALT-IT Trial Collaborators by country

UK (n = 4751)

Royal Stoke University Hospital (n = 303)

Raghavendra Kamath, Adrian Barry, Racquel Carpio, Kay Finney and Holly Maguire.

Queen’s Medical Centre Campus Nottingham (n = 208)

Martin James, Frank Coffey, Chris Gough, Lisa Sawers and Aye-Aye Thi.

Royal Berkshire Hospital (n = 191)

Jonathan Simmons, Claire Burnett, Nicola Jacques and Victoria Murray.

St George’s Hospital (n = 173)

Richard Pollok, Heather Jarman, Christine Lambe and Sarah Rounding.

Blackpool Victoria Hospital (n = 166)

Simon Tucker, Romaih Al-Idari, Samuel Guest and Emma Stoddard.

Queen Elizabeth Hospital Birmingham (n = 150)

David Yeo, Colin Bergin, Elaine Hardy and Joanne Thunder.

University Hospital Coventry (n = 128)

Paul Jhalli, Edward Hartley, Catherine Jarvis and Carly Swann.

Royal Infirmary of Edinburgh (n = 125)

Matthew Reed, Bernadette Gallagher, Julia Grahamslaw and Rachel O’Brien.

Royal London Hospital (n = 125)

Timothy Harris, Geoffrey Bellhouse, Olivia Boulton and Imogen Skene.

Glasgow Royal Infirmary (n = 120)

Adrian Stanley, Janet Johnstone, Donogh Maguire and Susan Thornton.

University College London Hospital (n = 113)

Matthew Banks, Georgia Bercades, Daniel Marks and Jung Ryu.

Whipps Cross University Hospital (n = 108)

Timothy Harris, Claire Dowty, Jason Pott and Imogen Skene.

John Radcliffe Hospital (n = 107)

James East, Adam Bailey, Sally Beer and Sian Davies.

Royal Devon & Exeter Hospital (n = 97)

Andrew Appelboam, Daisy Mackle and Jennifer Small.

Queen Alexandra Hospital Portsmouth (n = 88)

Christiane Vorwerk, Rachel Atkins and Isobel Bradbury.

Leicester Royal Infirmary (n = 84)

Timothy Coats, Catriona Bryceland and Lisa McClelland.

Salford Royal Hospital (n = 83)

Martin Thomas, Kate Clayton and Angiy Michael.

Great Western Hospital (n = 80)

Stephen Haig, Saif Al-Nahhas and Tim Godfrey.

Southampton General Hospital (n = 80)

Philip Boger, Rachel Comer and Barbara Watkins.

Darlington Memorial Hospital (n = 79)

Ola Afolabi, Shazad Afzal and Amanda Cowton.

St James University Hospital Leeds (n = 79)

Simon Everett, Ruth Fazakerley and Felicia Onoviran.

Poole Hospital (n = 77)

Jonathon Snook, Jackie Berry and Diane Simpson.

King’s College Hospital (n = 73)

Jeff Keep, Hannah Cotton and Sinead Helyar.

University Hospital of North Tees (n = 73)

Matthew Rutter, Tracey Johnston and Laura O’Rourke.

Basingstoke and North Hampshire Hospital (n = 72)

Louisa Chan, Joanna Tambellini and Dawn Trodd.

Dorset County Hospital (n = 68)

James Shutt, Sarah Moreton and Abby Oglesby.

Addenbrooke’s Hospital (n = 67)

Adrian Boyle, Nicola Haeger and Susie Hardwick.

Southmead Hospital (n = 67)

Jason Kendall, Beverley Faulkner and Ruth Worner.

Royal Victoria Infirmary (n = 64)

Sarah Hearnshaw, Mary Doona and Maria Price.

St Thomas’ Hospital (n = 64)

Laura Hunter, Maggie Bell and Vania Loureiro.

Derriford Hospital (n = 61)

Anthony Kehoe, Alison Jefferey and Rosalyn Squire.

Ipswich Hospital (n = 60)

David Hartin, Stephanie Bell and Alexandra Newman.

Musgrove Park Hospital (n = 59)

James Gagg, Jayne Foot and Sue Wakeford.

Royal Oldham Hospital (n = 58)

Gabrielle May, Thomas Bartram and Paul Cumpstay.

Whittington Hospital (n = 58)

Lucy Parker, Rita Das and Sheik Pahary.

Basildon University Hospital (n = 57)

Gavin Wright, Georgina Butt and Natasha Christmas.

Wexham Park Hospital (n = 56)

Sarah Wilson, Mohammed Ashfaq and Louise Chandler.

Royal United Hospital Bath (n = 50)

Saif Al-Nahhas, Carrie Demetriou and Philip Kaye.

Manchester Royal Infirmary (n = 48)

Simon Carley and Andrew Brown.

Chesterfield Royal Hospital (n = 44)

Lucy Jones and Amanda Whileman.

James Cook University Hospital (n = 44)

John Greenaway and Julie Tregonning.

Newham University Hospital (n = 44)

Timothy Harris and Geoffrey Bellhouse.

Northern General Hospital (n = 44)

Avril Kuhrt and Steve Goodacre.

Royal Shrewsbury Hospital (n = 43)

John Jones and Charlotte Owen.

Charing Cross Hospital (n = 41)

Anu Mitra and Abby Harper-Payne.

Sandwell General Hospital (n = 37)

Nigel Trudgill and Anne Hayes.

South Tyneside District Hospital (n = 36)

Faheem Butt and Gayle Clifford.

Victoria Hospital, Fife (n = 35)

Andrew Kinnon and Susan Fowler.

Chelsea and Westminster Hospital (n = 34)

Kris Pillay and Shweta Gidwani.

Queen Elizabeth Hospital Woolwich (n = 34)

Alistair McNair and Omer Omer.

Gloucestershire Royal Hospital (n = 31)

Tanya de Weymarn and Adnan Amin.

Royal Hampshire County Hospital (n = 31)

Louisa Chan and Jane Martin.

Torbay Hospital (n = 31)

Nick Mathieu and Simon Barnes.

York Hospital (n = 31)

James Turvill and Helen Sweeting.

University Hospital Crosshouse (n = 29)

Morten Draegebo and Marion McNaught.

Worthing Hospital (n = 29)

Mandy Grocutt and Jordi Margalef.

Barnsley Hospital (n = 27)

Julia Humphrey and Richard Jackson.

North Devon District Hospital (n = 27)

Fionn Bellis and Jane Hunt.

St Mary’s Hospital (n = 24)

Anu Mitra.

University Hospital Ayr (n = 22)

Alastair Stevenson.

King’s Mill Hospital (n = 19)

Nicholas Watson.

Royal Sussex County Hospital (n = 19)

Steven Barden.

Forth Valley Royal Hospital (n = 16)

Stuart Paterson.

New Cross Hospital (n = 16)

Andrew Veitch.

Cumberland Infirmary Hospital (n = 14)

Chris Macdonald.

Sunderland Royal Hospital (n = 14)

David Hobday.

West Cumberland Hospital (n = 13)

Olu Orugun.

Yeovil District Hospital (n = 13)

Andrew Allison.

Northampton General Hospital (n = 12)

Tristan Dyer.

Royal Lancaster Infirmary (n = 12)

Samuel McBride.

Royal Liverpool University Hospital (n = 12)

Wojciech Sawicki.

Hull Royal Infirmary (n = 10)

Ben Rayner.

Frimley Park Hospital (n = 8)

Lynsey Flowerdew.

Queen Elizabeth Hospital – Gateshead (n = 7)

Jamie Barbour.

Salisbury District Hospital (n = 7)

Jason Klein.

Aintree University Hospital (n = 6)

Stephen Hood.

University Hospital of Wales (n = 5)

Nicola Palmer.

Northwick Park Hospital (n = 4)

Jacob de Wolff.

Colchester General Hospital (n = 3)

Achuth Shenoy.

Birmingham City Hospital (n = 2)

Nigel Trudgill.

Royal Bournemouth Hospital (n = 1)

Peter Swallow.

University Hospital Lewisham (n = 1)

Rajaventhan Srirajaskanthan.

Pakistan (n = 4420)

King Edward Medical University, Mayo Hospital Lahore (n = 539)

Irshad Hussain, Hamza Arshad, Naeem Aslam, Anam Bangash, Muhammad Qamar and Haroon Zahoor.

Rawalpindi Medical University Pakistan, Holy Family Hospital, Unit II (n = 501)

Muttiullah Mutti, Saba Arshad, Quratul ain Ghalib, Tehseen Hameed, Tayyaba Saif and Wajahat Shafi.

Services Institute of Medical Sciences/Services Hospital GI/Medical Unit III Lahore (n = 443)

Muhammad Arif Nadeem, Abid Ali, Shehroze Khan, Muhammad Muaaz and Ahmad Taj.

Lady Reading Hospital (n = 386)

Aamir Ghafoor, Aamir Afridi, Mansoor Ahmad, Mujahid Aslam and Sandeep Kumar.

Asian Institute of Medical Sciences (n = 360)

Majid Soomro, Mohsin Ali, Ubedullah Bughio, Adil Chang and Sana Shaikh.

Jinnah Postgraduate Medical Centre Karachi (n = 296)

Syed Ahmad, Zeeshan Ali, Marium Waqar, Aiman Mushir and Sadaf Sattar.

DHQ Teaching Hospital Sargodha (n = 207)

Saifullah Goraya, Sharmeen Aslam, Nighat Fatima, Saadia Noreen and Sheraz Saleem.

Rawalpindi Medical University Pakistan, Benazir Bhutto Hospital Unit I (n = 196)

Fazal Rahman, Nadeem Iqbal, Mohammad Khalid and Umar Riaz.

Rawalpindi Medical University Pakistan, Holy Family Hospital, Unit I (n = 169)

Muhammad Umar, Tayyab Akhter, Javaria Khan and Noureen Misbah.

Aziz Bhatti Shaheed Teaching Hospital (n = 160)

Muhammad Afzal, Mobeen Kayani, Syed Shah and Shahida Tarar.

Bolan Medical Complex Hospital (n = 149)

Sherbat Khan, Yasir Iqbal, Essa Khan and Maqbool Reki.

Rawalpindi Medical University Pakistan, Benazir Bhutto Hospital Unit II (n = 120)

Tanveer Hussain, Shafqat Iqbal, Muhammad Khurram and Muhammad Shafi.

Ghulam Muhammad Mahar Medical College and Teaching Hospital Unit I (n = 120)

Abrar Shaikh, Aijaz Ahmed, Ameet Kumar and Pinkey Sachdev.

Jinnah Hospital Unit I (n = 88)

Khalid Mahmood Nasir, Zafar Iqbal Chaudhry and Muhammad Zubair.

Lahore General Hospital Medical Unit I (n = 84)

Ghias Tayyab, Junaid Mushtaq and Muhammad Nasir.

Mardan Medical Complex and Teaching Hospital (n = 80)

Amir Khan, Amjad Ali and Sajjad Ali.

POF Hospital (n = 76)

Wasim Uddin, Sohaib Ahmed and Tazaeen Kazmi.

Ghulam Muhammad Mahar Medical College Teaching Hospital (n = 58)

Saleh Channa, Adeeqa Aman and Mouzam Shaikh.

DHQ Hospital Faisalabad (n = 47)

Tahir Rizvi and Amjad Hussain.

Rawalpindi Medical University Pakistan, DHQ Hospital Rawalpindi (n = 47)

Haider Zaigham Baqai and Zakawat Rasheed.

Shifa International Hospital (n = 41)

Abdus Khan and Adeela Irfan.

Allied Hospital Faisalabad Medical Unit III (n = 38)

Aamir Husain and Asifa Aslam.

Madinah Teaching Hospital Faisalabad (n = 34)

Khalid Yahya and Salman Azhar.

Liaquat National Hospital and Postgraduate Medical Centre (n = 33)

Mansoor Ul Haq and Adeel Afzal.

Services Institute of Medical Sciences/Services Hospital GI/Medical Unit II Lahore (n = 33)

Muhammad Imran and Iram Saeed.

Shaukat Khanum Memorial Hospital and Research Centre (n = 29)

Aasim Yusuf and Mariam Hassan.

Hayatabad Medical Complex (n = 25)

Mumtaz Marwat and Muhammad Ishfaq.

Sir Ganga Ram Hospital Medical Unit III (n = 20)

Tahir Bashir.

Liaquat University of Medical and Health Sciences Medical Unit II (n = 17)

Santosh Kumar.

DHQ Hospital, Narowal (n = 16)

Sajjad Yaqoob.

DHQ Hospital Khuzdar (n = 8)

Abdul Wahid.

Nigeria (n = 770)

University College Hospital Ibadan (n = 143)

Adegboyega Akere, Tinuola Fakoya, Temitope Oke and Edries Tejan.

National Hospital Abuja (n = 109)

Oluwole Olaomi, Olawale Badejo, Okafor Nnaemaka and Nancy Ukwu.

Obafemi Awolowo University Teaching Hospital, Ile-Ife (n = 99)

Olukayode Arowolo, Adewale Aderounmu and Funmilola Wuraola.

University of Benin Teaching Hospital (n = 74)

Rose Ugiagbe, Alexander Atiri and Enadeghe Eghaghe.

Olabisi Onabanjo University Teaching Hospital (n = 49)

Adeleke Adekoya, Adedayo Oluyomi Tade and Olatunji Shonoiki.

University of Ilorin Teaching Hospital (n = 49)

Samuel Olatoke and Toafiq Raji.

Federal Medical Centre, Owerri (n = 46)

Christopher Ekwunife and Chigozirim Onyekpere.

Ahmadu Bello University Teaching Hospital (n = 40)

Adamu Ahmed and Daniyan Muhammad.

Lagos University Teaching Hospital (n = 37)

Emuobor Odeghe, Olufunmilayo Lesi and Azeberoje Osueni.

Aminu Kano Teaching Hospital (n = 25)

Adamu Samaila and Aminu Nahuche.

Ekiti State University Teaching Hospital (n = 24)

Akande Ajayi.

Irrua Specialist Teaching Hospital (n = 24)

Andrew Dongo.

University of Nigeria Teaching Hospital, Enugu (n = 18)

Uchenna Ijoma.

Federal Medical Centre, Abeokuta (n = 8)

Ademola Tolulope Adebanjo.

Lagos State University Teaching Hospital (n = 7)

Rufina Igetei.

University of Abuja Teaching Hospital (n = 7)

Monday Yilkudi.

Maitama District Hospital (n = 6)

Kehinde Osisanya.

Jos University Teaching Hospital (n = 3)

Edith Nonyelum Okeke.

Imo State University Teaching Hospital (n = 2)

Oguamanam Okezie Enwere.

Egypt (n = 709)

Kasr Al Aini Internal Medicine Hospital, Cairo University (n = 641)

Serag Esmat, Omar Ashoush, Mazen Naga, Fady Nagy, Mostafa Saiid and Ahmed Shaker.

Mataria Teaching Hospital (n = 60)

Hussein Khamis, Ashraf Helmy and Saafan Saafan.

Badr Hospital, Helwan University (n = 8)

Mohammed Abdel Monem.

Malaysia (n = 464)

Hospital Tengku Ampuan Afzan (n = 123)

Jiffre Din, Khairul Azis, Muhyuddin Brukan and Sanjay Singh.

Hospital Universiti Sains Malaysia (n = 110)

Andee Zakaria, Shaik Farid, Nizam Hashim and Masykurin Mafauzy.

Hospital Sultanah Bahiyah (n = 71)

Wan Najmi, Nil Amri and Xin Yi.

Hospital Raja Permaisuri Bainun (n = 63)

Mohammad Hisyam, Elaine Ng and Zuhrirahimi Ramli.

Pulau Pinang General Hospital (n = 55)

Shyang Yee Lim, Kelvin Voon and Sir Young Yam.

Sungai Buloh Hospital (n = 42)

Mohammad Jahit and Lee Joon.

Georgia (n = 425)

High Technology Medical Centre, University Clinic (n = 364)

Besik Melikidze, Davit Kazaishvili, Tamar Gogichaishvili, Nino Grubelashvili and Baadur Mosidze.

Centre of Emergency Surgery and Traumatology (n = 61)

Gia Tomadze and Avto Megreladze.

Romania (n = 287)

Clinical Emergency Hospital Bucharest – SCUB Floreasca (n = 128)

Ruxandra Oprita, Dorina Pestroiu Calescu, Camèlia Chioncel and Andrei Ragea.

Colentina Clinical Hospital (n = 58)

Bogdan Mateescu, Bogdan Busuioc and Andrei Voiosu.

Municipal Emergency Hospital Moinesti (n = 45)

Adrian Cotirlet and Iulia Pintilie.

Central University Emergency Military Hospital, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest (n = 38)

Mariana Jinga and Daniel Balaban.

Regional Institute of Gastroenterology and Hepatology ‘Prof Dr Octavian Fodor’ (n = 11)

Marcel Tanţău.

University Hospital of Emergency Bucharest (n = 5)

Lucian Negreanu.

Emergency County Hospital Mures (n = 2)

Simona Bataga.

Nepal (n = 50)

Lifeline Hospital (n = 16)

Khushboo Priya.

Gandaki Medical College and Teaching Hospital (n = 12)

Shankar Baral.

Nepal Medical College and Teaching Hospital (n = 12)

Anuj KC.

Janaki Medical College (n = 4)

Vijay Sah.

National Medical College and Teaching Hospital (n = 4)

Vijay Yadav.

Lumbini Medical College and Teaching Hospital (n = 2)

Ajay Adhikaree.

Sudan (n = 40)

Ibn Sina Hospital (n = 40)

Abdelmounem Abdo and Dalia Ahmed.

Saudi Arabia (n = 19)

Prince Mohammed Bin Abdulaziz Hospital (n = 19)

Marzouqah Al Anazi and Areej Al Balkhi.

Ireland (n = 17)

Cork University Hospital (n = 17)

Conor Deasy.

Spain (n = 17)

Hospital Nuestra Señora del Prado (n = 9)

Joaquín Álvarez Gregori.

Torrecardenas Hospital (n = 8)

Helio Fornieles Pérez.

Albania (n = 16)

University Hospital Centre ‘Mother Teresa’ (n = 16)

Arben Beqiri.

Papua New Guinea (n = 13)

Port Moresby General Hospital (n = 13)

Bobby Wellsh.

Australia (n = 11)

The Townsville Hospital (n = 11)

Luke Lawton.

Copyright © 2021 Roberts et al. This work was produced by Roberts et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This is an Open Access publication distributed under the terms of the Creative Commons Attribution CC BY 4.0 licence, which permits unrestricted use, distribution, reproduction and adaption in any medium and for any purpose provided that it is properly attributed. See: https://creativecommons.org/licenses/by/4.0/. For attribution the title, original author(s), the publication source – NIHR Journals Library, and the DOI of the publication must be cited.
Bookshelf ID: NBK574623
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