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Pohlmann A, Niendorf T, editors. Preclinical MRI of the Kidney: Methods and Protocols [Internet]. New York: Humana Press; 2021. doi: 10.1007/978-1-0716-0978-1_18

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Preclinical MRI of the Kidney: Methods and Protocols [Internet].

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Table 1

Factors confounding the tissue stiffness measured using MRE

Confounding factorDirection of effectExamples scenarios
Iron/T2*Loss of SNRPatients with B-Thalassemia
InflammationPositivePatients with AIH
CongestionPositivePatients with Fontan
Magnetic-field (B0) inhomogeneityPositiveBowel gas, poor shim
Steatosis/fatNegativePatients with NAFLD, NASH
Renal stenosisNegativePatients with renal artery stenosis or perfusion defects
Renal perfusionPositiveLarge hydration volume or higher renal perfusion pressure can alter renal stiffness

A “positive” direction of the effect means that an increase in the confounding factor leads to an increase in measured stiffness and hence an overestimation of the fibrosis, and a “negative” direction of the effect means that decreases the confounding factor lead to a potential under estimation of stiffness

From: Chapter 18, MR Elastography of the Abdomen: Basic Concepts

Copyright 2021, The Author(s)

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