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Pohlmann A, Niendorf T, editors. Preclinical MRI of the Kidney: Methods and Protocols [Internet]. New York: Humana Press; 2021. doi: 10.1007/978-1-0716-0978-1_10

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Preclinical MRI of the Kidney: Methods and Protocols [Internet].

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Table 1

Factors confounding the relationship between R2*(or T2*), oxygen saturation of hemoglobin, and blood pO2

Confounding factorDirection of effectExamples scenarios
Blood volume fractionPositiveVasodilation/constriction, change in tubular volume fraction
HematocritPositivePlasma skimming, hemodilution
Oxygen–hemoglobin dissociation curveChanges in pH, pCO2, or temperature
Magnetic field (B0) inhomogeneityPositiveBowel gas, poor shim
T2PositiveEdema

A “positive” direction of the effect means that an increase in the confounding factor leads to an increase in R2* (decrease in T2*) and hence an overestimation of the hypoxia

From: Chapter 10, MRI Mapping of the Blood Oxygenation Sensitive Parameter T2* in the Kidney: Basic Concept

Copyright 2021, The Author(s)

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