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Le A, editor. The Heterogeneity of Cancer Metabolism [Internet]. 2nd edition. Cham (CH): Springer; 2021. doi: 10.1007/978-3-030-65768-0_7

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The Heterogeneity of Cancer Metabolism [Internet]. 2nd edition.

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Fig. 1. The effect of thiamine on lactate and acetyl-CoA production.

Fig. 1

The effect of thiamine on lactate and acetyl-CoA production. Some cancer cells produce lactate even in the presence of oxygen, an effect known as the Warburg effect. Lactic acidosis can result from unregulated lactic acid (lactate) buildup. When thiamine is present, there is a mixture of lactate and acetyl-CoA (left). When thiamine is deficient, acetyl-CoA production is impaired, and pyruvate is mainly converted to lactate resulting in lactate buildup (right)

From: Non-Hodgkin Lymphoma Metabolism

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