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Thompson W, McCormack S. Interventions to Influence the Use of Antibiotics for Acute Upper Respiratory Tract Infections [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2021 Feb.

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Interventions to Influence the Use of Antibiotics for Acute Upper Respiratory Tract Infections [Internet].

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Table 1Selection Criteria

CriteriaDescription
PopulationPeople of any age with suspected acute URTIs (e.g., cough, sore throat, AOM, uncomplicated pharyngitis, tonsillitis, rhinitis, common cold, influenza, uncomplicated sinusitis)
Intervention

Q1: Delayed antibiotic prescription filling

Q2: Family medicine interventions to influence the use of antibiotics, used alone or in combinations, such as but not limited to:

  • clinical decision rules, tool, or score charts (e.g., FeverPAIN score)
  • point-of-care testing (e.g., C-reactive protein, procalcitonin, streptococcal antigen, multi-viral PCR),
  • alternate “prescriptions” (e.g., “prescriptions” for lifestyle measure, comfort care)

ComparatorQ1 and Q2: Standard of care (e.g., immediate antibiotic prescription filling; no prescribed antibiotics)
OutcomesQ1 and Q2: Clinical benefits (e.g., fever, pain, swelling, quality of life, number of consultations for the same illness) and harms (e.g., over-or underprescribing, hospital admissions, emergency department visits, morbidity [e.g., complications], mortality)
Study DesignsHTAs and SRs

AOM = acute otitis media; HTA = health technology assessment; PCR = polymerase chain reaction; Q = question; SR = systematic review; URTI = upper respiratory tract infections.

From: Interventions to Influence the Use of Antibiotics for Acute Upper Respiratory Tract Infections

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