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Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: Interim Progress and Surveillance Reports [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2020 Dec-.
Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: Interim Progress and Surveillance Reports [Internet].
Show detailsTable 4Characteristics of included randomized controlled trials
| Characteristic | THC/CBD | THC | Synthetic THC | CBD | CBDV |
|---|---|---|---|---|---|
| THC to CBD Ratio | Comparable | High | High | Low | NA - other cannabinoids |
| Source | Plant-extracted | Plant-extracted | Synthetic | Plant-extracted | Plant-extracted |
| N Studies | 7 | 2 | 9 | 1 | 1 |
|
Risk of Bias % High, % Moderate, % Low | 29%, 57%, 14% | 0%, 50%, 50% | 22%, 44%, 33% | 100% high | 100% moderate |
| Total Randomized | 882 | 297 | 534 | 29 | 34 |
| Age, Mean Years | 53 | 52 | 50 | 68 | 50 |
| Female, % | 66% | 89% | 61% | 38% | 3% |
| % Non-Whitea | 1.6% (2) | 1% (1) | 5.4% (3) | NA | NA |
| Primary Pain Type (n studies) | NPP (6) | NPP (1) | NPP (6) | NPP (1) | NPP (1) |
| Baseline Pain Score, Mean (Range)b | 6.59 (5.3 to 7.3) | 8.47 (8.25 to 8.67) | 6.46 (4 to 8.1)c | 5.38 (4.67 to 6.14) | 6.28 (6.12 to 6.44) |
| Study Duration | 4 to 15 weeks | 8 to 12 weeks | 4 to 47 weeks | 4 weeks | 4 weeks |
Abbreviations: CBD = cannabidiol; CBDV = cannabidivarin; NA = not applicable; NPP = neuropathic pain; THC = tetrahydrocannabinol.
- a
(n) = number of studies reporting this characteristic at baseline.
- b
Scores were standardized to a 0 to 10 scale.
- c
Weighted mean includes median scores for 1 study (6 vs. 6).
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- Mus musculus mnb protein kinase homolog mp86 (Dyrk) mRNA, complete cdsMus musculus mnb protein kinase homolog mp86 (Dyrk) mRNA, complete cdsgi|1126522628|gb|U58497.2|MMU58497Nucleotide
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