Table 15, Key Question 2: Results for CT Colonography Test Accuracy - Screening for Colorectal Cancer: An Evidence Update for the U.S. Preventive Services Task Force

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Lin JS, Perdue LA, Henrikson NB, et al. Screening for Colorectal Cancer: An Evidence Update for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2021 May. (Evidence Synthesis, No. 202.)

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Screening for Colorectal Cancer: An Evidence Update for the U.S. Preventive Services Task Force [Internet].

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Table 15Key Question 2: Results for CT Colonography Test Accuracy

Bowel prep	Author, year	Number screened	Prevalence, n (%)	CRC	Advanced adenoma		Adenoma ≥10 mm		Adenoma ≥6 mm
Bowel prep	Author, year	Number screened	Prevalence, n (%)	Sensitivity (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)
With bowel prep	Lefere, 2013¹⁸⁴	496	CRC: 4 (0.8) AA: 28 (5.6) A10: NR A6: 49 (9.9)	1.0 (0.51, 1.0)	1.0 (0.87, 1.0)	0.87 (0.84, 0.90)	NR	NR	0.98 (0.89, 1.0)	0.91 (0.88, 0.93)
	Graser, 2009¹⁷²	307	CRC: 1 (0.33) AA: 29 (9.4) A10: 24 (7.8) A6: 45 (14.6)	1.0 (0.21, 1.0)	0.97 (0.83, 0.99)	0.39 (0.34, 0.45)	0.92 (0.74, 0.99)	0.98 (0.95, 0.99)	0.91 (0.79, 0.98)	0.93 (0.89, 0.96)
	Johnson, 2008¹⁷⁷	2531	CRC: 7 (0.28) AA: NR A10: 102 (4.0) A6: 203 (8.0)	0.86 (0.49, 0.97)	NR	NR	0.90 (0.83, 0.95)	0.86 (0.85, 0.87)	0.78 (0.72, 0.83)	0.88 (0.87, 0.89)
	Kim, 2008¹⁸¹	241	CRC: 1 (0.4) AA: 16 (6.6) A10: 10 (4.1) A6: 44 (18.3)	1.0 (0.21, 1.0)	0.88 (0.64, 0.96)	NR	0.87^*^† (0.62, 0.96)	0.97^*^† (0.94, 0.99)	0.68^*^† (0.55, 0.79)	0.88^*^† (0.84, 0.92)
	Johnson, 2007¹⁷⁸	452	CRC: 5 (1.1) AA: NR^* A10: 21 (4.6) A6: NR 51 (11.3)	1.0 (0.56, 1.0)	NR	NR	0.67 (0.45, 0.83)	0.98 (0.96, 0.99)	NR	NR
	Macari, 2004¹⁸⁸	68	CRC: NR AA: NR A10: 3 (4.4)^* A6: NR	NR	NR	NR	1.0^* (0.44, 1.0)	0.98^* (0.92, 1.0)	NR	NR
	Pickhardt, 2003¹⁹⁵	1233	CRC: 2 (0.16) AA: NR^* A10: 46 A6: 166	1.0 (0.34, 1.0)	NR	NR	0.94 (0.82, 0.98)	0.96 (0.95, 0.97)	0.89 (0.83, 0.93)	0.80 (0.77, 0.82)
Without bowel prep	Fletcher, 2013¹⁶⁹	564	CRC: 1 (0.18) AA: 25 (4.4) A10: 15 (2.6) A6: 36 (6.4)	1.0 (0.03, 1.0)	0.64 (0.44, 0.80)	NR	0.67 (0.42, 0.85)	0.97 (0.96, 0.98)	0.75 (0.59, 0.86)	0.92 (0.90, 0.94)
Without bowel prep	Zalis, 2012²⁰⁵	605	CRC: 3 (0.5) AA: NR A10: 19 (3.1) A6: 71 (11.7)	1.0 (0.44, 1.0)	NR	NR	0.90 (0.69, 0.97)	0.85 (0.82, 0.88)	0.58 (0.46, 0.69)	0.88 (0.85, 0.91)

*: Any histology
†: Sensitivity for adenomas ≥6 mm 0.73 (95% CI, 0.57 to 0.85); Sensitivity for adenomas ≥10 mm 0.9 (95% CI, 0.56 to 1.0)
: Abbreviations: AA = advanced adenoma; A6 = adenoma ≥6 mm; A10 = adenoma ≥10 mm; CI = confidence interval; CRC = colorectal cancer; n = number; NR = not reported.

From: Chapter 3, Results

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Lin JS, Perdue LA, Henrikson NB, et al. Screening for Colorectal Cancer: An Evidence Update for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2021 May. (Evidence Synthesis, No. 202.) Table 15, Key Question 2: Results for CT Colonography Test Accuracy.
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