Appendix Table 9.5c, Estimated Outcomes for 10-Yearly Sigmoidoscopy Plus Interval FIT Strategies: MISCAN - Colorectal Cancer Screening: An Updated Decision Analysis for the U.S. Preventive Services Task Force

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Knudsen AB, Rutter CM, Peterse EFP, et al. Colorectal Cancer Screening: An Updated Decision Analysis for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2021 May. (Technical Report, No. 202s.)

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Colorectal Cancer Screening: An Updated Decision Analysis for the U.S. Preventive Services Task Force [Internet].

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Appendix Table 9.5cEstimated Outcomes for 10-Yearly Sigmoidoscopy Plus Interval FIT Strategies: MISCAN

Strategy	Outcomes per 1000 unscreened 40-year-olds free from diagnosed colorectal cancer											DLG
Strategy	Stool tests	SIGs	CTCs	Screening COLs	Other COLs^*	Total COLs	Complications	CRC cases	CRC deaths^†	LYG	QALYG	DLG
No screening	0	0	0	0	81	81	2	81	34	0	0	0
SIG+FIT 45-70, 10_1	13812	2055	0	0	2148	2148	11	40	10	292	261	107
SIG+FIT 45-70, 10_2	7965	2209	0	0	1947	1947	11	42	11	280	250	102
SIG+FIT 45-75, 10_1	15466	2393	0	0	2331	2331	13	37	9	304	272	111
SIG+FIT 45-75, 10_2	9117	2593	0	0	2130	2130	12	39	9	294	262	108
SIG+FIT 45-80, 10_1	16683	2393	0	0	2379	2379	13	37	8	307	274	112
SIG+FIT 45-80, 10_2	9673	2593	0	0	2154	2154	12	39	9	296	264	108
SIG+FIT 45-85, 10_1	17634	2570	0	0	2463	2463	14	37	8	309	275	113
SIG+FIT 45-85, 10_2	10336	2795	0	0	2235	2235	14	39	8	298	265	109
SIG+FIT 50-70, 10_1	10831	1900	0	0	1984	1984	11	40	10	282	251	103
SIG+FIT 50-70, 10_2	6482	2038	0	0	1835	1835	11	42	11	274	243	100
SIG+FIT 50-75, 10_1	12357	1900	0	0	2048	2048	12	39	10	287	255	105
SIG+FIT 50-75, 10_2	7177	2038	0	0	1867	1867	11	41	10	277	246	101
SIG+FIT 50-80, 10_1	13676	2161	0	0	2185	2185	13	38	8	293	260	107
SIG+FIT 50-80, 10_2	8098	2335	0	0	2005	2005	13	40	9	284	251	104
SIG+FIT 50-85, 10_1	14548	2161	0	0	2218	2218	14	38	8	294	260	107
SIG+FIT 50-85, 10_2	8496	2335	0	0	2021	2021	13	40	9	284	251	104
SIG+FIT 55-70, 10_1	7944	1389	0	0	1680	1680	11	43	12	250	222	91
SIG+FIT 55-70, 10_2	4622	1462	0	0	1547	1547	10	45	13	241	213	88
SIG+FIT 55-75, 10_1	9625	1730	0	0	1871	1871	12	40	10	263	233	96
SIG+FIT 55-75, 10_2	5792	1851	0	0	1739	1739	12	42	11	256	225	93
SIG+FIT 55-80, 10_1	10851	1730	0	0	1920	1920	13	40	10	266	235	97
SIG+FIT 55-80, 10_2	6351	1851	0	0	1764	1764	12	42	10	258	227	94
SIG+FIT 55-85, 10_1	11807	1908	0	0	2004	2004	14	40	9	268	236	98
SIG+FIT 55-85, 10_2	7018	2054	0	0	1847	1847	14	42	10	260	228	95

: COL – colonoscopy; SIG – sigmoidoscopy; FIT – fecal immunochemical test with a cutoff for positivity of 20 μg of hemoglobin per g of feces; CTC – computed tomographic colonography; CRC – colorectal cancer; LYG – life-years gained compared with no screening; QALYG – quality-adjusted life-years gained compared with no screening; DLG – days of life gained per person, compared with no screening
*: Colonoscopies for follow-up, surveillance, and symptom diagnosis
†: Includes deaths from complications of screening
: Note: Analyses assume an increased population risk of colorectal cancer based on an incidence rate ratio comparing colorectal cancer incidence among 20- to 44-year-olds in 2012-2016 vs 1975-1979 of 1.19.

From: Appendix 9, Model-Estimated Outcomes for Each Strategy Within a Screening Modality

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Knudsen AB, Rutter CM, Peterse EFP, et al. Colorectal Cancer Screening: An Updated Decision Analysis for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2021 May. (Technical Report, No. 202s.) Appendix Table 9.5c, Estimated Outcomes for 10-Yearly Sigmoidoscopy Plus Interval FIT Strategies: MISCAN.
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