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Knudsen AB, Rutter CM, Peterse EFP, et al. Colorectal Cancer Screening: An Updated Decision Analysis for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2021 May. (Technical Report, No. 202s.)
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Colorectal Cancer Screening: An Updated Decision Analysis for the U.S. Preventive Services Task Force [Internet].
Show detailsAppendix Table 9.5cEstimated Outcomes for 10-Yearly Sigmoidoscopy Plus Interval FIT Strategies: MISCAN
Strategy | Outcomes per 1000 unscreened 40-year-olds free from diagnosed colorectal cancer | DLG | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Stool tests | SIGs | CTCs | Screening COLs | Other COLs* | Total COLs | Complications | CRC cases | CRC deaths† | LYG | QALYG | ||
No screening | 0 | 0 | 0 | 0 | 81 | 81 | 2 | 81 | 34 | 0 | 0 | 0 |
SIG+FIT 45-70, 10_1 | 13812 | 2055 | 0 | 0 | 2148 | 2148 | 11 | 40 | 10 | 292 | 261 | 107 |
SIG+FIT 45-70, 10_2 | 7965 | 2209 | 0 | 0 | 1947 | 1947 | 11 | 42 | 11 | 280 | 250 | 102 |
SIG+FIT 45-75, 10_1 | 15466 | 2393 | 0 | 0 | 2331 | 2331 | 13 | 37 | 9 | 304 | 272 | 111 |
SIG+FIT 45-75, 10_2 | 9117 | 2593 | 0 | 0 | 2130 | 2130 | 12 | 39 | 9 | 294 | 262 | 108 |
SIG+FIT 45-80, 10_1 | 16683 | 2393 | 0 | 0 | 2379 | 2379 | 13 | 37 | 8 | 307 | 274 | 112 |
SIG+FIT 45-80, 10_2 | 9673 | 2593 | 0 | 0 | 2154 | 2154 | 12 | 39 | 9 | 296 | 264 | 108 |
SIG+FIT 45-85, 10_1 | 17634 | 2570 | 0 | 0 | 2463 | 2463 | 14 | 37 | 8 | 309 | 275 | 113 |
SIG+FIT 45-85, 10_2 | 10336 | 2795 | 0 | 0 | 2235 | 2235 | 14 | 39 | 8 | 298 | 265 | 109 |
SIG+FIT 50-70, 10_1 | 10831 | 1900 | 0 | 0 | 1984 | 1984 | 11 | 40 | 10 | 282 | 251 | 103 |
SIG+FIT 50-70, 10_2 | 6482 | 2038 | 0 | 0 | 1835 | 1835 | 11 | 42 | 11 | 274 | 243 | 100 |
SIG+FIT 50-75, 10_1 | 12357 | 1900 | 0 | 0 | 2048 | 2048 | 12 | 39 | 10 | 287 | 255 | 105 |
SIG+FIT 50-75, 10_2 | 7177 | 2038 | 0 | 0 | 1867 | 1867 | 11 | 41 | 10 | 277 | 246 | 101 |
SIG+FIT 50-80, 10_1 | 13676 | 2161 | 0 | 0 | 2185 | 2185 | 13 | 38 | 8 | 293 | 260 | 107 |
SIG+FIT 50-80, 10_2 | 8098 | 2335 | 0 | 0 | 2005 | 2005 | 13 | 40 | 9 | 284 | 251 | 104 |
SIG+FIT 50-85, 10_1 | 14548 | 2161 | 0 | 0 | 2218 | 2218 | 14 | 38 | 8 | 294 | 260 | 107 |
SIG+FIT 50-85, 10_2 | 8496 | 2335 | 0 | 0 | 2021 | 2021 | 13 | 40 | 9 | 284 | 251 | 104 |
SIG+FIT 55-70, 10_1 | 7944 | 1389 | 0 | 0 | 1680 | 1680 | 11 | 43 | 12 | 250 | 222 | 91 |
SIG+FIT 55-70, 10_2 | 4622 | 1462 | 0 | 0 | 1547 | 1547 | 10 | 45 | 13 | 241 | 213 | 88 |
SIG+FIT 55-75, 10_1 | 9625 | 1730 | 0 | 0 | 1871 | 1871 | 12 | 40 | 10 | 263 | 233 | 96 |
SIG+FIT 55-75, 10_2 | 5792 | 1851 | 0 | 0 | 1739 | 1739 | 12 | 42 | 11 | 256 | 225 | 93 |
SIG+FIT 55-80, 10_1 | 10851 | 1730 | 0 | 0 | 1920 | 1920 | 13 | 40 | 10 | 266 | 235 | 97 |
SIG+FIT 55-80, 10_2 | 6351 | 1851 | 0 | 0 | 1764 | 1764 | 12 | 42 | 10 | 258 | 227 | 94 |
SIG+FIT 55-85, 10_1 | 11807 | 1908 | 0 | 0 | 2004 | 2004 | 14 | 40 | 9 | 268 | 236 | 98 |
SIG+FIT 55-85, 10_2 | 7018 | 2054 | 0 | 0 | 1847 | 1847 | 14 | 42 | 10 | 260 | 228 | 95 |
COL – colonoscopy; SIG – sigmoidoscopy; FIT – fecal immunochemical test with a cutoff for positivity of 20 μg of hemoglobin per g of feces; CTC – computed tomographic colonography; CRC – colorectal cancer; LYG – life-years gained compared with no screening; QALYG – quality-adjusted life-years gained compared with no screening; DLG – days of life gained per person, compared with no screening
- *
Colonoscopies for follow-up, surveillance, and symptom diagnosis
- †
Includes deaths from complications of screening
Note: Analyses assume an increased population risk of colorectal cancer based on an incidence rate ratio comparing colorectal cancer incidence among 20- to 44-year-olds in 2012-2016 vs 1975-1979 of 1.19.
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