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Sergi CM, editor. Liver Cancer [Internet]. Brisbane (AU): Exon Publications; 2021 Apr 6. doi: 10.36255/exonpublications.livercancer.2021.ch7

Cover of Liver Cancer

Liver Cancer [Internet].

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Table 1

Selection Criteria for Liver Transplantation

Milan criteria
  • Most common eligibility criteria for LT among patients with HCC
  • Single lesion ≤5 cm, or up to 3 lesions each ≤3 cm
  • No evidence of extra-hepatic metastases or vascular invasion
Expanded criteria
  • UCSF: Single lesion ≤6.5 cm or ≤3 lesions with the largest being ≤4.5 cm and a total diameter ≤8 cm
  • Up-to-7: 7 cm as the sum of the size of the largest tumor and the number of tumors. No vascular invasion.
  • Toronto criteria: Any tumor size or number. All lesions require a liver biopsy and must NOT show poor differentiation. No extra-hepatic metastasis, venous/biliary thrombosis OR cancer related symptoms.
UNOS Criteria for Downstaging
  • Single lesion >5 cm but ≤8 cm
  • 2-3 lesions each ≤5 cm with total diameter of all lesions ≤8 cm
  • 4-5 lesions each ≤3 cm with total diameter of all lesions ≤8 cm

HCC, hepatocellular carcinoma; LT, liver transplant; MC, Milan Criteria; UCSF, University of California in San Francisco

From: Chapter 7, Locoregional Therapies for Bridging and Downstaging Hepatocellular Carcinoma Prior to Liver Transplant

Copyright: The Authors.

Licence: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). https://creativecommons.org/licenses/by-nc/4.0/

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