Figure 1, [Cellular structure and Alzheimer’s disease...]. - Alzheimer’s Disease: Drug Discovery

Warning: The NCBI web site requires JavaScript to function. more...

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Huang X, editor. Alzheimer’s Disease: Drug Discovery [Internet]. Brisbane (AU): Exon Publications; 2020 Dec 18. doi: 10.36255/exonpublications.alzheimersdisease.2020.ch7

Cover of Alzheimer’s Disease: Drug Discovery

Alzheimer’s Disease: Drug Discovery [Internet].

Show details

Contents

Figure 1

Cellular structure and Alzheimer’s disease (AD) specific changes in the blood–brain barrier (BBB). (A) Schematic representation of the BBB structure. The BBB is formed by brain endothelial cells (BECs) with astrocytes and pericytes functioning as key supporting cells. The BBB and other brain cells (neurons and microglia) form the neurovascular unit. (B) AD-specific changes in the BBB include altered tight junction and transporter expression in BECs, pericyte degradation, altered aquaporin-4 (AQP4) expression in astrocytes with these changes leading to increased permeability, reactive oxygen species (ROS) and neuroinflammation, and subsequent amyloid-β (Aβ) accumulation and neuronal loss. Created using BioRender.com.

From: Chapter 7, Modeling the Blood–Brain Barrier to Understand Drug Delivery in Alzheimer’s Disease

Licence: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). https://creativecommons.org/licenses/by-nc/4.0/

Contents

Views

Cite this Page
Wasielewska JM, Da Silva Chaves JC, White AR, et al. Modeling the Blood–Brain Barrier to Understand Drug Delivery in Alzheimer’s Disease. In: Huang X, editor. Alzheimer’s Disease: Drug Discovery [Internet]. Brisbane (AU): Exon Publications; 2020 Dec 18. Figure 1, [Cellular structure and Alzheimer’s disease...]. doi: 10.36255/exonpublications.alzheimersdisease.2020.ch7
PDF version of this title (17M)