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Brealey S, Northgraves M, Kottam L, et al. Surgical treatments compared with early structured physiotherapy in secondary care for adults with primary frozen shoulder: the UK FROST three-arm RCT. Southampton (UK): NIHR Journals Library; 2020 Dec. (Health Technology Assessment, No. 24.71.)

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Surgical treatments compared with early structured physiotherapy in secondary care for adults with primary frozen shoulder: the UK FROST three-arm RCT.

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Appendix 10Subgroup descriptive statistics (Oxford Shoulder Score)

TABLE 46

Unadjusted OSS by treatment arm and diabetes status

Time pointDiabetic (N = 150, 30%)Non-diabetic (N = 353, 70%)
MUAACRESPMUAACRESP
Baseline
n1411426912125
 Mean (SD)20.1 (8.43)19.3 (7.27)20.8 (8.48)24.8 (8.55)20.5 (9.26)20.8 (8.04)
 Median2019.5202322.521
 Minimum, maximum2, 404, 372, 4215, 486, 359, 30
3 months
n1271286412115
 Mean (SD)32.6 (10.05)28.9 (10.39)34.1 (9.75)33.9 (7.77)28.3 (11.46)35 (14.32)
 Median343136353240
 Minimum, maximum7, 485, 487, 4820, 469, 4314, 48
6 months
n125123601293
 Mean (SD)39.9 (8.24)37.7 (9.26)38.2 (9.37)36.6 (9.23)34.3 (11.74)33.3 (20.43)
 Median42404038.53642
 Minimum, maximum5, 489, 486, 4815, 487, 4610, 48
12 months
n1261226212105
 Mean (SD)40.4 (8.94)42.0 (8.43)40.8 (7.79)39.5 (6.67)39.2 (13.65)34.6 (11.78)
 Median43454338.54335
 Minimum, maximum7, 488, 4810, 4827, 483, 4820, 48

TABLE 47

Unadjusted OSS by treatment arm and previous physiotherapy

Time pointHad previous physiotherapy for affected shoulder (N = 308, 61%)Did not have previous physiotherapy for affected shoulder (N = 192, 38%)
MUAACRESPMUAACRESP
Baseline
n12512359757739
 Mean (SD)20.9 (8.25)19.3 (7.64)20.3 (8.54)19.8 (9.85)19.1 (7.78)20 (7.11)
 Median211919202020
 Minimum, maximum2, 402, 372, 422, 481, 376, 39
3 months
n11111258676632
 Mean (SD)31.4 (10.13)27.1 (11.40)32.3 (11.41)32.1 (10.93)28.2 (10.50)33.3 (10.20)
 Median342734.5343135.5
 Minimum, maximum7, 482, 474, 465, 488, 488, 48
6 months
n10810553696430
 Mean (SD)39.4 (9.01)36.4 (10.41)35.4 (11.95)37.4 (10.65)36.9 (9.12)38.5 (9.19)
 Median4239394039.540
 Minimum, maximum5, 487, 486, 483, 4810, 487, 48
12 months
n11510954686534
 Mean (SD)40.4 (8.67)40.4 (10.18)38.8 (10.53)37.7 (11.49)41.51 (9.48)39 (10.59)
 Median434442.5424542.5
 Minimum, maximum4, 482, 484, 485, 486, 4810, 48

TABLE 48

Unadjusted OSS by treatment arm and patient preference

Time pointRandomised to preferred treatment (N = 131, 26%)Randomised to non-preferred treatment (N = 105, 21%)Had no preference at baseline (N = 263, 52%)
MUAACRESPMUAACRESPMUAACRESP
Baseline
n56641139273810311049
 Mean (SD)18.8 (9.52)16.6 (7.30)25 (5.76)21.8 (8.73)20.2 (8.04)16.6 (8.08)20.9 (8.33)20.4 (7.62)21.8 (7.22)
 Median181525222016.5212121
 Minimum, maximum2, 381, 3116, 392, 484, 372, 422, 402, 376, 37
3 months
n475493624379410043
 Mean (SD)31.7 (11.31)26.0 (11.60)37.9 (5.49)29.6 (9.18)26.3 (10.79)28.6 (11.48)32.4 (10.44)28.3 (10.96)35.3 (10.35)
 Median3525.537302732353038
 Minimum, maximum5, 483, 4731, 457, 478, 446, 458, 482, 484, 48
6 months
n47539342432959242
 Mean (SD)37.6 (11.29)35.4 (9.82)41.6 (5.36)38.68 (6.83)36.3 (9.72)33.19 (11.87)39.0 (9.82)37.1 (10.21)37.9 (10.81)
 Median403843404037424041
 Minimum, maximum4, 4810, 4832, 4815, 4814, 486, 483, 487, 486, 48
12 months
n505310362434959743
 Mean (SD)39.2 (9.47)39.4 (9.84)42.7 (4.27)38.5 (8.57)41.0 (8.92)38.2 (10.19)40.0 (10.10)41.4 (10.39)38.8 (11.60)
 Median42.5424440.545.540.5444543
 Minimum, maximum4, 486, 4835, 4810, 4821, 4810, 485, 482, 484, 48

TABLE 49

Unadjusted OSS by treatment arm and duration of symptoms at baseline

Time pointDuration of symptoms: < 9 months (N = 249, 61%)Duration of symptoms: ≥ 9 months (N = 245, 49%)
MUAACRESPMUAACRESP
Baseline
n10395519310547
 Mean (SD)18.3 (8.33)18.8 (7.53)19.6 (7.53)22.7 (9.04)19.6 (7.90)21.0 (8.51)
 Median181918241921
 Minimum, maximum2, 362, 342, 391, 481, 374, 42
3 months
n888346869543
 Mean (SD)31.4 (10.21)28.2 (11.61)30.7 (10.89)32.0 (10.76)26.9 (10.60)34.5 (10.72)
 Median343132342736
 Minimum, maximum8, 462, 486, 485, 483, 474, 48
6 months
n898142848840
 Mean (SD)38.2 (10.42)37.2 (9.63)37.6 (8.35)39.0 (9.07)36.0 (10.05)35.1 (13.3)
 Median404140423940
 Minimum, maximum3, 487, 4812, 485, 4810, 486, 48
12 months
n948444869043
 Mean (SD)39.0 (11.35)40.9 (10.45)39.1 (10.02)40.0 (8.00)40.7 (9.60)38.5 (8.00)
 Median434543.5434443
 Minimum, maximum4, 482, 4810, 4810, 486, 4810, 48

TABLE 50

Unadjusted OSS for patients who completed treatment by receipt of steroid injection

Time pointMUAACRESP
Received steroid injectionDid not receive steroid injectionReceived steroid injectionDid not receive steroid injectionReceived steroid injectionDid not receive steroid injection
Baseline
n163456410
 Mean (SD)20.4 (8.89)18.1 (7.51)20.7 (6.83)18.1 (10.04)
 Median20182017
 Minimum, maximum2, 482, 336, 394, 34
12 months
n15740614
 Mean (SD)39.8 (9.33)42.1 (9.76)39.8 (10.21)28.5 (16.82)
 Median4345.54429
 Minimum, maximum4, 482, 4810, 4810, 46
Copyright © Queen’s Printer and Controller of HMSO 2020. This work was produced by Brealey et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
Bookshelf ID: NBK565281

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