Appendix 10Subgroup descriptive statistics (Oxford Shoulder Score)
TABLE 46
Unadjusted OSS by treatment arm and diabetes status
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Time point | Diabetic (N = 150, 30%) | Non-diabetic (N = 353, 70%) |
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MUA | ACR | ESP | MUA | ACR | ESP |
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Baseline |
n | 141 | 142 | 69 | 12 | 12 | 5 |
Mean (SD) | 20.1 (8.43) | 19.3 (7.27) | 20.8 (8.48) | 24.8 (8.55) | 20.5 (9.26) | 20.8 (8.04) |
Median | 20 | 19.5 | 20 | 23 | 22.5 | 21 |
Minimum, maximum | 2, 40 | 4, 37 | 2, 42 | 15, 48 | 6, 35 | 9, 30 |
3 months |
n | 127 | 128 | 64 | 12 | 11 | 5 |
Mean (SD) | 32.6 (10.05) | 28.9 (10.39) | 34.1 (9.75) | 33.9 (7.77) | 28.3 (11.46) | 35 (14.32) |
Median | 34 | 31 | 36 | 35 | 32 | 40 |
Minimum, maximum | 7, 48 | 5, 48 | 7, 48 | 20, 46 | 9, 43 | 14, 48 |
6 months |
n | 125 | 123 | 60 | 12 | 9 | 3 |
Mean (SD) | 39.9 (8.24) | 37.7 (9.26) | 38.2 (9.37) | 36.6 (9.23) | 34.3 (11.74) | 33.3 (20.43) |
Median | 42 | 40 | 40 | 38.5 | 36 | 42 |
Minimum, maximum | 5, 48 | 9, 48 | 6, 48 | 15, 48 | 7, 46 | 10, 48 |
12 months |
n | 126 | 122 | 62 | 12 | 10 | 5 |
Mean (SD) | 40.4 (8.94) | 42.0 (8.43) | 40.8 (7.79) | 39.5 (6.67) | 39.2 (13.65) | 34.6 (11.78) |
Median | 43 | 45 | 43 | 38.5 | 43 | 35 |
Minimum, maximum | 7, 48 | 8, 48 | 10, 48 | 27, 48 | 3, 48 | 20, 48 |
TABLE 47
Unadjusted OSS by treatment arm and previous physiotherapy
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Time point | Had previous physiotherapy for affected shoulder (N = 308, 61%) | Did not have previous physiotherapy for affected shoulder (N = 192, 38%) |
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MUA | ACR | ESP | MUA | ACR | ESP |
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Baseline |
n | 125 | 123 | 59 | 75 | 77 | 39 |
Mean (SD) | 20.9 (8.25) | 19.3 (7.64) | 20.3 (8.54) | 19.8 (9.85) | 19.1 (7.78) | 20 (7.11) |
Median | 21 | 19 | 19 | 20 | 20 | 20 |
Minimum, maximum | 2, 40 | 2, 37 | 2, 42 | 2, 48 | 1, 37 | 6, 39 |
3 months |
n | 111 | 112 | 58 | 67 | 66 | 32 |
Mean (SD) | 31.4 (10.13) | 27.1 (11.40) | 32.3 (11.41) | 32.1 (10.93) | 28.2 (10.50) | 33.3 (10.20) |
Median | 34 | 27 | 34.5 | 34 | 31 | 35.5 |
Minimum, maximum | 7, 48 | 2, 47 | 4, 46 | 5, 48 | 8, 48 | 8, 48 |
6 months |
n | 108 | 105 | 53 | 69 | 64 | 30 |
Mean (SD) | 39.4 (9.01) | 36.4 (10.41) | 35.4 (11.95) | 37.4 (10.65) | 36.9 (9.12) | 38.5 (9.19) |
Median | 42 | 39 | 39 | 40 | 39.5 | 40 |
Minimum, maximum | 5, 48 | 7, 48 | 6, 48 | 3, 48 | 10, 48 | 7, 48 |
12 months |
n | 115 | 109 | 54 | 68 | 65 | 34 |
Mean (SD) | 40.4 (8.67) | 40.4 (10.18) | 38.8 (10.53) | 37.7 (11.49) | 41.51 (9.48) | 39 (10.59) |
Median | 43 | 44 | 42.5 | 42 | 45 | 42.5 |
Minimum, maximum | 4, 48 | 2, 48 | 4, 48 | 5, 48 | 6, 48 | 10, 48 |
TABLE 48
Unadjusted OSS by treatment arm and patient preference
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Time point | Randomised to preferred treatment (N = 131, 26%) | Randomised to non-preferred treatment (N = 105, 21%) | Had no preference at baseline (N = 263, 52%) |
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MUA | ACR | ESP | MUA | ACR | ESP | MUA | ACR | ESP |
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Baseline |
n | 56 | 64 | 11 | 39 | 27 | 38 | 103 | 110 | 49 |
Mean (SD) | 18.8 (9.52) | 16.6 (7.30) | 25 (5.76) | 21.8 (8.73) | 20.2 (8.04) | 16.6 (8.08) | 20.9 (8.33) | 20.4 (7.62) | 21.8 (7.22) |
Median | 18 | 15 | 25 | 22 | 20 | 16.5 | 21 | 21 | 21 |
Minimum, maximum | 2, 38 | 1, 31 | 16, 39 | 2, 48 | 4, 37 | 2, 42 | 2, 40 | 2, 37 | 6, 37 |
3 months |
n | 47 | 54 | 9 | 36 | 24 | 37 | 94 | 100 | 43 |
Mean (SD) | 31.7 (11.31) | 26.0 (11.60) | 37.9 (5.49) | 29.6 (9.18) | 26.3 (10.79) | 28.6 (11.48) | 32.4 (10.44) | 28.3 (10.96) | 35.3 (10.35) |
Median | 35 | 25.5 | 37 | 30 | 27 | 32 | 35 | 30 | 38 |
Minimum, maximum | 5, 48 | 3, 47 | 31, 45 | 7, 47 | 8, 44 | 6, 45 | 8, 48 | 2, 48 | 4, 48 |
6 months |
n | 47 | 53 | 9 | 34 | 24 | 32 | 95 | 92 | 42 |
Mean (SD) | 37.6 (11.29) | 35.4 (9.82) | 41.6 (5.36) | 38.68 (6.83) | 36.3 (9.72) | 33.19 (11.87) | 39.0 (9.82) | 37.1 (10.21) | 37.9 (10.81) |
Median | 40 | 38 | 43 | 40 | 40 | 37 | 42 | 40 | 41 |
Minimum, maximum | 4, 48 | 10, 48 | 32, 48 | 15, 48 | 14, 48 | 6, 48 | 3, 48 | 7, 48 | 6, 48 |
12 months |
n | 50 | 53 | 10 | 36 | 24 | 34 | 95 | 97 | 43 |
Mean (SD) | 39.2 (9.47) | 39.4 (9.84) | 42.7 (4.27) | 38.5 (8.57) | 41.0 (8.92) | 38.2 (10.19) | 40.0 (10.10) | 41.4 (10.39) | 38.8 (11.60) |
Median | 42.5 | 42 | 44 | 40.5 | 45.5 | 40.5 | 44 | 45 | 43 |
Minimum, maximum | 4, 48 | 6, 48 | 35, 48 | 10, 48 | 21, 48 | 10, 48 | 5, 48 | 2, 48 | 4, 48 |
TABLE 49
Unadjusted OSS by treatment arm and duration of symptoms at baseline
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Time point | Duration of symptoms: < 9 months (N = 249, 61%) | Duration of symptoms: ≥ 9 months (N = 245, 49%) |
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MUA | ACR | ESP | MUA | ACR | ESP |
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Baseline |
n | 103 | 95 | 51 | 93 | 105 | 47 |
Mean (SD) | 18.3 (8.33) | 18.8 (7.53) | 19.6 (7.53) | 22.7 (9.04) | 19.6 (7.90) | 21.0 (8.51) |
Median | 18 | 19 | 18 | 24 | 19 | 21 |
Minimum, maximum | 2, 36 | 2, 34 | 2, 39 | 1, 48 | 1, 37 | 4, 42 |
3 months |
n | 88 | 83 | 46 | 86 | 95 | 43 |
Mean (SD) | 31.4 (10.21) | 28.2 (11.61) | 30.7 (10.89) | 32.0 (10.76) | 26.9 (10.60) | 34.5 (10.72) |
Median | 34 | 31 | 32 | 34 | 27 | 36 |
Minimum, maximum | 8, 46 | 2, 48 | 6, 48 | 5, 48 | 3, 47 | 4, 48 |
6 months |
n | 89 | 81 | 42 | 84 | 88 | 40 |
Mean (SD) | 38.2 (10.42) | 37.2 (9.63) | 37.6 (8.35) | 39.0 (9.07) | 36.0 (10.05) | 35.1 (13.3) |
Median | 40 | 41 | 40 | 42 | 39 | 40 |
Minimum, maximum | 3, 48 | 7, 48 | 12, 48 | 5, 48 | 10, 48 | 6, 48 |
12 months |
n | 94 | 84 | 44 | 86 | 90 | 43 |
Mean (SD) | 39.0 (11.35) | 40.9 (10.45) | 39.1 (10.02) | 40.0 (8.00) | 40.7 (9.60) | 38.5 (8.00) |
Median | 43 | 45 | 43.5 | 43 | 44 | 43 |
Minimum, maximum | 4, 48 | 2, 48 | 10, 48 | 10, 48 | 6, 48 | 10, 48 |
TABLE 50
Unadjusted OSS for patients who completed treatment by receipt of steroid injection
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Time point | MUA | ACR | ESP |
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Received steroid injection | Did not receive steroid injection | Received steroid injection | Did not receive steroid injection | Received steroid injection | Did not receive steroid injection |
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Baseline |
n | 163 | – | 45 | – | 64 | 10 |
Mean (SD) | 20.4 (8.89) | | 18.1 (7.51) | | 20.7 (6.83) | 18.1 (10.04) |
Median | 20 | | 18 | | 20 | 17 |
Minimum, maximum | 2, 48 | | 2, 33 | | 6, 39 | 4, 34 |
12 months |
n | 157 | – | 40 | – | 61 | 4 |
Mean (SD) | 39.8 (9.33) | | 42.1 (9.76) | | 39.8 (10.21) | 28.5 (16.82) |
Median | 43 | | 45.5 | | 44 | 29 |
Minimum, maximum | 4, 48 | | 2, 48 | | 10, 48 | 10, 46 |