The objective of this report was to perform a systematic review of the beneficial and harmful effects of Certolizumab pegol 400 mg and 200 mg every two weeks administered as an subcutaneous injection for the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy.

Contents

• Abbreviations
• Executive Summary
  • Introduction
  • Results and Interpretation
  • Conclusions
• Introduction
  • Disease Prevalence and Incidence
  • Standards of Therapy
  • Drug
• Objectives and Methods
  • Objectives
  • Methods
• Results
  • Findings From the Literature
  • Included Studies
  • Exposure to Study Treatments
  • Critical Appraisal
  • Efficacy
  • Harms
• Discussion
  • Summary of Available Evidence
  • Interpretation of Results
• Conclusions
• Appendix 1. Patient Input Summary
• Appendix 2. Literature Search Strategy
• Appendix 3. Excluded Studies
• Appendix 4. Detailed Outcome Data
• Appendix 5. Validity of Outcome Measures
• Appendix 6. Summary of Other Studies
• Appendix 7. Summary of Indirect Comparisons
• References

Version: Final (with redactions)

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