Conclusion 7-1

There is limited and mixed quality evidence to suggest that estriol may be effective in treating certain menopausal symptoms; however, there is insufficient evidence to inform conclusions regarding the safety of estriol. Well-designed and properly controlled clinical trials are needed to clarify the potential clinical utility of estriol.

Conclusion 7-2

There is insufficient evidence to determine the safety and effectiveness of compounded estriol in comparison to bioidentical hormone therapy products approved by FDA or similar international bodies.

From: 7, The Safety and Effectiveness of Compounded Bioidentical Hormone Therapy

Cover of The Clinical Utility of Compounded Bioidentical Hormone Therapy
The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use.
National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Sciences Policy; Committee on the Clinical Utility of Treating Patients with Compounded Bioidentical Hormone Replacement Therapy; Jackson LM, Parker RM, Mattison DR, editors.
Washington (DC): National Academies Press (US); 2020 Jul 1.
Copyright 2020 by the National Academy of Sciences. All rights reserved.

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