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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Figure 4Steady-state kinetics data for the determination of Kic for 12-hLO with inhibitor
KM/Vmax (slope, KM units are μM) versus [Inhibitor] (μM) is the secondary replot of the inhibition data, which yielded a Kic of 0.8 +/− 0.1μM.
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- PubChem BioAssay for Chemical ProbePubChem BioAssay records reporting screening data for the development of the chemical probe(s) described in this book chapter
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- Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.[J Med Chem. 2010]Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, et al. J Med Chem. 2010 Oct 28; 53(20):7392-404.
- Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.[J Med Chem. 2011]Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB 2nd, Perry S, Joshi N, Bougie JM, Leister W, et al. J Med Chem. 2011 Aug 11; 54(15):5485-97. Epub 2011 Jul 8.
- Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.[Bioorg Med Chem. 2007]Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.Deschamps JD, Gautschi JT, Whitman S, Johnson TA, Gassner NC, Crews P, Holman TR. Bioorg Med Chem. 2007 Nov 15; 15(22):6900-8. Epub 2007 Aug 22.
- Review Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1.[Probe Reports from the NIH Mol...]Review Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1.Rai G, Joshi N, Perry S, Yasgar A, Schultz L, Jung JE, Liu Y, Terasaki Y, Diaz G, Kenyon V, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Review Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase.[Probe Reports from the NIH Mol...]Review Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase.Luci D, Jameson JB II, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Figure 4, Steady-state kinetics data for the determination of Kic for 12-hLO wit...Figure 4, Steady-state kinetics data for the determination of Kic for 12-hLO with inhibitor - Probe Reports from the NIH Molecular Libraries Program
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