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NTP Technical Report on the Toxicology Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (CASRN 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies): Technical Report 589 [Internet].
National Toxicology Program.
Research Triangle Park (NC): National Toxicology Program; 2016 Feb.
Table of contents
Results.
Appendix M, Study on the Relationship of the AhR to DE-71 Liver Tumor Formation in Wistar Han Rats.
Merrick BA, Dunnick JK, Maynor T, et al.
Appendix I, Tissue Concentration Studies.
Appendix D, Summary of Lesions in Female Mice in the Two-year Gavage Study of DE-71.
Introduction.
Appendix A, Summary of Lesions in F1 Male Wistar Han Rats in the Two-year Perinatal and Postnatal Gavage Study of DE-71.
Appendix C, Summary of Lesions in Male Mice in the Two-year Gavage Study of DE-71.
Appendix B, Summary of Lesions in F1 Female Wistar Han Rats in the Two-year Perinatal and Postnatal Gavage Study of DE-71.
Appendix N, Evaluation of Hras and Ctnnb1 Mutations in Hepatocellular Tumors from Wistar Han Rats and B6C3F1/N Mice Chronically Exposed to DE-71.
Materials and Methods.
Appendix G, Organ Weights and Organ-Weight-to-Body-Weight Ratios.
Appendix E, Genetic Toxicology.
Conclusions.
Discussion.
References.
Appendix O, Summary of Peer Review Panel Comments.
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