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NTP Technical Report on the Toxicology Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (CASRN 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies): Technical Report 589 [Internet].
National Toxicology Program.
Research Triangle Park (NC): National Toxicology Program; 2016 Feb.
Table of contents
Results.
Appendix E, Genetic Toxicology.
Appendix J, Chemical Characterization and Dose Formulation Studies.
Materials and Methods.
Introduction.
Appendix N, Evaluation of Hras and Ctnnb1 Mutations in Hepatocellular Tumors from Wistar Han Rats and B6C3F1/N Mice Chronically Exposed to DE-71.
Appendix I, Tissue Concentration Studies.
Appendix M, Study on the Relationship of the AhR to DE-71 Liver Tumor Formation in Wistar Han Rats.
Merrick BA, Dunnick JK, Maynor T, et al.
Appendix A, Summary of Lesions in F1 Male Wistar Han Rats in the Two-year Perinatal and Postnatal Gavage Study of DE-71.
Appendix H, Reproductive Tissue Evaluations and Estrous Cycle Characterization.
Appendix B, Summary of Lesions in F1 Female Wistar Han Rats in the Two-year Perinatal and Postnatal Gavage Study of DE-71.
Appendix K, Ingredients, Nutrient Composition, and Contaminant Levels in NTP-2000 Rat and Mouse Ration.
Appendix D, Summary of Lesions in Female Mice in the Two-year Gavage Study of DE-71.
Appendix C, Summary of Lesions in Male Mice in the Two-year Gavage Study of DE-71.
Appendix G, Organ Weights and Organ-Weight-to-Body-Weight Ratios.
Appendix L, Sentinel Animal Program.
Appendix F, Clinical Pathology Results.
Peer Review.
Conclusions.
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