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Show detailsContinuing Education Activity
Cervical cerclage is performed as an attempt to prolong pregnancy in certain women who are at higher risk of preterm delivery. Cerclage placement may be indicated by a history of cervical insufficiency or by certain sonographic or physical exam findings in a current pregnancy. The McDonald and Shirodkar techniques, or modifications thereof, are the most commonly used methods for placing a cerclage. This activity reviews the indications, contraindications, and techniques for performing a cervical cerclage and highlights the role of the interprofessional team in evaluating, treating, and managing patients who are candidates for this procedure.
Objectives:
- Describe the risk factors for cervical insufficiency.
- Identify the indications for cervical cerclage placement.
- Outline the common methods of a cervical cerclage procedure.
Introduction
Throughout the natural course of pregnancy, the cervix remains long, thick and firm until the late third trimester when it slowly begins to soften, dilate and efface to eventually allow the passage of a fetus. The inability of a cervix to maintain its integrity prior to that time can result in miscarriage or preterm birth. When this occurs in the absence of clinical signs or symptoms of labor, it is referred to as cervical insufficiency or incompetence. In the past, nonsurgical approaches such as activity restriction and pelvic rest have been suggested, though their use has not proven effective and should be discouraged.[1] Cervical cerclage is a surgical procedure that can be performed in an attempt to maintain the structural integrity of the cervix in order to prolong gestation and improve obstetrical outcomes.
Anatomy and Physiology
The pathophysiology behind cervical insufficiency is still not well understood but is thought to arise from a structural or functional defect of the cervix. Risk factors include any prior cervical procedures or trauma, including loop electrode excisional procedure, cone biopsy, prior cervical lacerations, and repetitive cervical dilation and/or pregnancy terminations. Other possible etiologies include maternal connective tissue diseases or abnormalities, congenital Mullerian anomalies, or maternal exposure in utero to diethylstilbestrol.[1][2]
Indications
There are three well-accepted indications for cervical cerclage placement. According to the American College of Obstetricians and Gynecologists (ACOG), a history-indicated or prophylactic cerclage may be placed when there is a “history of one or more second-trimester pregnancy losses related to painless cervical dilation and in the absence of labor or abruptio placentae,” or if the woman had a prior cerclage placed due to cervical insufficiency in the second trimester.
An ultrasound-indicated cerclage may be considered for women who have a history of spontaneous loss or preterm birth at less than 34 weeks gestation if the cervical length in a current singleton pregnancy is noted to be less than 25 mm before 24 weeks of gestation. It is important to note that this recommendation is invalidated without the history of preterm birth.
Physical examination-indicated cerclage (also known as emergency or rescue cerclage) should be considered for patients with a singleton pregnancy at less than 24 weeks gestation with advanced cervical dilation in the absence of contractions, intraamniotic infection or placental abruption.[1][3]
Contraindications
While ACOG does not list any absolute contraindications, special attention should be given to the considerations listed above. Additionally, cerclage is not recommended in pregnancies of multiple gestations.[1]
Technique or Treatment
The most common technique for performing transvaginal cervical cerclage is the McDonald method. First applied in 1951, this procedure involves a simple purse-string suture at the cervicovaginal junction. Under regional anesthesia, the patient is placed in the dorsal lithotomy position and prepped with a vaginal betadine solution. A speculum or right-angle retractors are used to adequately visualize the cervix. The anterior lip of the cervix may be gently grasped using ring polyp forceps, and the vesicocervical junction should be identified. Just anterior to this junction, a nonabsorbable suture is inserted into the cervix in a purse-string manner, taking caution to avoid the paracervical vessels. The suture is then tied down with a surgeon knot, either anterior or posterior.[4]
The Shirodkar technique begins with the patient positioned and prepared in the same manner. Once the vesicocervical reflection has been identified, the mucosa of the anterior cervix is incised at this junction, similar to a vaginal hysterectomy. An Allis clamp can be used to elevate the bladder flap while the bladder is then mobilized cephalad using blunt or sharp dissection. This is continued until reaching the level of the internal cervical os. A similar incision is then made in the posterior cervical mucosa. Again, an Allis clamp can be used for traction on the posterior mucosa, while the reflection of the Pouch of Douglas is created using blunt dissection. An Allis clamp can then be applied at the 9 o’clock position to retract and isolate the paracervical vessels. A nonabsorbable suture can then be passed from anterior to posterior just beneath the Allis clamp so as not to enter the cervical os. The Allis should then be removed and placed in a similar fashion at the 3 o’clock position. The suture can then be passed from posterior to anterior, with special attention to lay the suture flat against the posterior aspect of the cervix. The suture can then be securely tied anteriorly. The anterior and posterior mucosa can then each be reapproximated in order to bury the cerclage stitch. This may be done in the running or interrupted fashion using an absorbable suture. The free ends of the cerclage stitch may be left exposed to facilitate subsequent removal.[4]
Both ultrasound-indicated and physical examination-indicated cerclages should be placed prior to 24 weeks gestation. Women undergoing a history-indicated cerclage procedure should have placement between 12-14 weeks gestation.[5][6] There have been no proven clinical benefits to routine post-cerclage cervical length surveillance.[7] Studies have demonstrated the comparative efficacy of McDonald and Shirodkar techniques. Thus, due to relative ease of placement and removal of the McDonald cerclage, that technique tends to be used more frequently. There is also a consideration for abdominal cerclage placement for women who have failed a previous transvaginal cerclage.[8]
Cervical cerclages should be removed between 36-38 weeks of gestation, prior to the onset of labor. Removal can safely be performed in the office setting. If preterm labor is suspected or diagnosed, cerclage should be removed at that time to minimize potential trauma to the cervix. If a cesarean is planned, removal may be delayed until the time of surgery.[1][8]
Complications
This procedure is not without risk, but the ultrasound-indicated and physical examination-indicated cerclages likely incur more risk than history-indicated cerclages. Risks include infection or sepsis, inadvertent rupture of membranes, lacerations at the surgical site, and anesthesia-related complications. Recent reviews suggest that initial dilation greater than 4cm is associated with a poor prognosis.[9] These risks must be weighed against the benefit of the structural support of the cervix.
Clinical Significance
Preterm birth is a major cause of neonatal morbidity and mortality. One of the most significant risk factors for preterm birth is a history of preterm delivery, and one etiology of preterm birth is cervical insufficiency. Cervical cerclages have been used to prevent preterm birth since the 1950s, yet their efficacy continues to be questioned and studied. A 2017 Cochrane review supports that “pregnant women with cerclage were less likely to have preterm births compared to controls before 37, 34, and 28 completed weeks of gestation.”[5] However, outcomes may vary based on indication for cerclage.
A meta-analysis showed that patients undergoing elective cerclage delivered at a significantly higher gestational age and had significantly higher birth weights compared to those undergoing emergency cerclage. Additionally, there was a higher incidence of premature rupture of membranes in the emergency cerclage group.[10] While each patient and situation deserves its own individual consideration, cervical cerclage should remain an instrument for the indications described above.
Enhancing Healthcare Team Outcomes
Cervical cerclage is a common obstetric procedure performed in an attempt to improve cervical integrity, prolong gestation, and prevent preterm birth. A cerclage may be indicated by history, ultrasound findings, or physical exam. They should be performed by a skilled obstetrician for the indications described above. Through a combined effort of the patient in obtaining early prenatal care, the radiologist in taking careful cervical length measurements, and the obstetrician in conducting a thorough history and physical exam, it is possible that neonatal morbidity and mortality can be reduced via cerclage placement in select populations.
References
- 1.
- ACOG Practice Bulletin No.142: Cerclage for the management of cervical insufficiency. Obstet Gynecol. 2014 Feb;123(2 Pt 1):372-379. [PubMed: 24451674]
- 2.
- Brown R, Gagnon R, Delisle MF., MATERNAL FETAL MEDICINE COMMITTEE. Cervical insufficiency and cervical cerclage. J Obstet Gynaecol Can. 2013 Dec;35(12):1115-1127. [PubMed: 24405880]
- 3.
- Gluck O, Mizrachi Y, Ginath S, Bar J, Sagiv R. Obstetrical outcomes of emergency compared with elective cervical cerclage. J Matern Fetal Neonatal Med. 2017 Jul;30(14):1650-1654. [PubMed: 27491941]
- 4.
- Wood SL, Owen J. Cerclage: Shirodkar, McDonald, and Modifications. Clin Obstet Gynecol. 2016 Jun;59(2):302-10. [PubMed: 26974218]
- 5.
- Alfirevic Z, Stampalija T, Medley N. Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev. 2017 Jun 06;6(6):CD008991. [PMC free article: PMC6481522] [PubMed: 28586127]
- 6.
- Suhag A, Berghella V. Cervical cerclage. Clin Obstet Gynecol. 2014 Sep;57(3):557-67. [PubMed: 24979354]
- 7.
- Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org. McIntosh J, Feltovich H, Berghella V, Manuck T. The role of routine cervical length screening in selected high- and low-risk women for preterm birth prevention. Am J Obstet Gynecol. 2016 Sep;215(3):B2-7. [PubMed: 27133011]
- 8.
- Sperling JD, Dahlke JD, Gonzalez JM. Cerclage Use: A Review of 3 National Guidelines. Obstet Gynecol Surv. 2017 Apr;72(4):235-241. [PubMed: 28426125]
- 9.
- Naqvi M, Barth WH. Emergency Cerclage: Outcomes, Patient Selection, and Operative Considerations. Clin Obstet Gynecol. 2016 Jun;59(2):286-94. [PubMed: 27101238]
- 10.
- Chen Q, Chen G, Li N. Clinical effect of emergency cervical cerclage and elective cervical cerclage on pregnancy outcome in the cervical-incompetent pregnant women. Arch Gynecol Obstet. 2018 Feb;297(2):401-407. [PubMed: 29222640]
Disclosure: Katie Bieber declares no relevant financial relationships with ineligible companies.
Disclosure: Stephen Olson declares no relevant financial relationships with ineligible companies.
- Review [Prevention of preterm birth by uterine cervical cerclage].[J Gynecol Obstet Biol Reprod (...]Review [Prevention of preterm birth by uterine cervical cerclage].Marcellin L. J Gynecol Obstet Biol Reprod (Paris). 2016 Dec; 45(10):1299-1323. Epub 2016 Oct 29.
- Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.[Cochrane Database Syst Rev. 2020]Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.Eleje GU, Eke AC, Ikechebelu JI, Ezebialu IU, Okam PC, Ilika CP. Cochrane Database Syst Rev. 2020 Sep 24; 9(9):CD012871. Epub 2020 Sep 24.
- Recurrence of second trimester miscarriage and extreme preterm delivery at 16-27 weeks of gestation with a focus on cervical insufficiency and prophylactic cerclage.[Acta Obstet Gynecol Scand. 2016]Recurrence of second trimester miscarriage and extreme preterm delivery at 16-27 weeks of gestation with a focus on cervical insufficiency and prophylactic cerclage.Sneider K, Christiansen OB, Sundtoft IB, Langhoff-Roos J. Acta Obstet Gynecol Scand. 2016 Dec; 95(12):1383-1390.
- Cervical insufficiency and cervical cerclage.[J Obstet Gynaecol Can. 2013]Cervical insufficiency and cervical cerclage.Brown R, Gagnon R, Delisle MF, MATERNAL FETAL MEDICINE COMMITTEE. J Obstet Gynaecol Can. 2013 Dec; 35(12):1115-1127.
- Review Cervical cerclage for short cervix at 24 to 26 weeks of gestation: systematic review and meta-analysis of randomized controlled trials using individual patient-level data.[Am J Obstet Gynecol MFM. 2023]Review Cervical cerclage for short cervix at 24 to 26 weeks of gestation: systematic review and meta-analysis of randomized controlled trials using individual patient-level data.Gulersen M, Lenchner E, Nicolaides KH, Otsuki K, Rust OA, Althuisius S, Bornstein E, Berghella V. Am J Obstet Gynecol MFM. 2023 Jun; 5(6):100930. Epub 2023 Mar 15.
- Cervical Cerclage - StatPearlsCervical Cerclage - StatPearls
- LDHD [Hyaena hyaena]LDHD [Hyaena hyaena]Gene ID:120248196Gene
- Chain B, ATP synthase subunit c, chloroplasticChain B, ATP synthase subunit c, chloroplasticgi|407943644|pdb|3V3C|BProtein
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