Mechanism of Action of Valproic Acid

Mechanism of Action of Valproic Acid. The figure illustrates the metabolic pathway of GABA synthesis and its metabolism involving α-ketoglutarate dehydrogenase, GABA transaminase, and succinate dehydrogenase. Valproic acid effectively inhibits the activity of the 2 catabolic enzymes involved in GABA metabolism, leading to the elevation in GABA levels within the central nervous system. Contributed by Masum Rahman

From: Valproic Acid

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