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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 53608-75-6
Drug Levels and Effects
Summary of Use during Lactation
Pancrelipase has been used in mothers of breastfed infants with apparent allergy to proteins in breastmilk derived from the maternal diet. This technique seems to have improved symptoms of egg allergy and cow’s milk allergy, such as blood in the stool and colic.[1-3] Pancreatic enzymes are not appreciably absorbed from the mother’s gastrointestinal tract, so they should not reach the infant. Expert opinion considers use of pancrelipase to be acceptable during breastfeeding.[4,5]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Des Roches A, Abbott M, Begin P, et al. Oral pancreatic enzyme supplements can reduce excretion of ovalbumin in breast milk. J Investig Allergol Clin Immunol 2014;24:62-3. [PubMed: 24765885]
- 2.
- Repucci A. Resolution of stool blood in breast-fed infants with maternal ingestion of pancreatic enzymes J Pediatr Gastroenterol Nutr;29:500. Abstract.
- 3.
- Schach B, Haight M. Colic and food allergy in the breastfed infant: Is it possible for an exclusively breastfed infant to suffer from food allergy? J Hum Lact 2002;18:50-2. [PubMed: 11845737]
- 4.
- Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J 2020;55:1901208. [PubMed: 31699837]
- 5.
- ABM Clinical Protocol #24: Allergic proctocolitis in the exclusively breastfed infant. Breastfeed Med 2011;6:435-40. [PubMed: 22050274]
Substance Identification
Substance Name
Pancrelipase
CAS Registry Number
53608-75-6
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- In Vitro Comparison of Physical Parameters, Enzyme Activity, Acid Resistance, and pH Dissolution Characteristics of Enteric-Coated Pancreatic Enzyme Preparations: Implications for Clinical Variability and Pharmacy Substitution.[J Pediatr Pharmacol Ther. 2007]In Vitro Comparison of Physical Parameters, Enzyme Activity, Acid Resistance, and pH Dissolution Characteristics of Enteric-Coated Pancreatic Enzyme Preparations: Implications for Clinical Variability and Pharmacy Substitution.Kuhn RJ, Eyting S, Henniges F, Potthoff A. J Pediatr Pharmacol Ther. 2007 Apr; 12(2):115-28.
- Pancreatic enzymes prepared in bicarbonate solution for administration through enteral feeding tubes.[Am J Health Syst Pharm. 2015]Pancreatic enzymes prepared in bicarbonate solution for administration through enteral feeding tubes.Boullata AM, Boullata JI. Am J Health Syst Pharm. 2015 Jul 15; 72(14):1210-4.
- World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guidelines update - X - Breastfeeding a baby with cow's milk allergy.[World Allergy Organ J. 2023]World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guidelines update - X - Breastfeeding a baby with cow's milk allergy.McWilliam V, Netting MJ, Volders E, Palmer DJ, WAO DRACMA Guideline Group. World Allergy Organ J. 2023 Nov; 16(11):100830. Epub 2023 Nov 3.
- Consensus statement on diagnosis, treatment and follow-up of cow's milk protein allergy among infants and children in Turkey.[Turk J Pediatr. 2016]Consensus statement on diagnosis, treatment and follow-up of cow's milk protein allergy among infants and children in Turkey.Kansu A, Yüce A, Dalgıç B, Şekerel BE, Çullu-Çokuğraş F, Çokuğraş H. Turk J Pediatr. 2016; 58(1):1-11.
- Review Assessment of Evidence About Common Infant Symptoms and Cow's Milk Allergy.[JAMA Pediatr. 2020]Review Assessment of Evidence About Common Infant Symptoms and Cow's Milk Allergy.Munblit D, Perkin MR, Palmer DJ, Allen KJ, Boyle RJ. JAMA Pediatr. 2020 Jun 1; 174(6):599-608.
- Pancrelipase - Drugs and Lactation Database (LactMed®)Pancrelipase - Drugs and Lactation Database (LactMed®)
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