“Allopatch is minimally processed, which better preserves and maintains the graft’s natural biomechanical and biochemical properties. Unlike other ECMs [extracellular membranes] that need to be hydrated for 60 minutes or more before being used, delaying procedure completion and prolonging OR time, Allopatch requires no refrigeration or hydration and is ready to use off the shelf almost immediately.”

3-year shelf life at ambient temperature.

“The graft provides a favorable microenvironment for bio-ingrowth to begin revascularization and cellular repopulation. Single application often sufficient to potentially help stimulate the wound healing process. Ready-to-use off the shelf. Pliable and stretchable for contouring to wound topography and maintenance of wound bed contact. Robust enough to suture or staple. Meshed (1:1) encouraging fluid drainage from wound.”

Ready-to-use, shelf-stable graft with room temperature storage, eliminating the need for costly cryo freezers.

“Skin allografts mechanically protect the wound and provide biologic factors native to human skin, which may help stimulate the wound healing process. AlloSource’s process uses electron beam irradiation to yield a ready-to-use, shelf-stable graft with room temperature storage, eliminating the need for costly cryo freezers. Pliable and stretchable, AlloSkin RT allows graft contouring to wound topography, yet is robust enough to suture or staple graft without tearing. In addition, 1:1 meshing encourages exudate drainage from wound, allowing the graft to be secure to the surface and avoid ‘floating’.”

Ready-to-use, shelf-stable graft with room temperature storage, eliminating the need for costly cryo freezers

“The natural collagen and elastin matrix is ideal for neovascularization and cellular proliferation. Coll-e-Derm maintains the strength of human skin and provides a natural scaffold for cellular and capillary remodeling of a damaged site, which can expedite the healing process. Benefits: Terminally Sterile at 10-6 with low dose precision gamma irradiation, lowering risk of infection.

Supplied lyophilized at room temperature for easy storage and handling.”

“DermaSpan Acellular Dermal Matrix is very carefully processed to offer biocompatibility as well as biomechanical strength in tendon coverage or reinforcement and wound coverage procedures. DermaSpan Acellular Dermal Matrix has the added advantage of being supplied sterile…unlike many other dermal allograft products.”

Does not need refrigeration.

“A single application of this product is often sufficient to stimulate the wound healing process. The pliable, flexible material adheres to wound topography and maintains contact with the wound bed. It’s also durable enough to suture or staple and has a mesh construction to encourage fluid drainage. FlowerDerm is ready for use right off the shelf.”

Stored at room temperature, 2-year shelf life.

“GammaGraft has unrivalled ease of use and safety and provides one of the easiest biological grafts for patient compliance. Promethean’s proprietary technology sterilizes and preserves the tissues. This technique leads to safer grafts as well as ones that are easier to handle and use. Many doctors and nurses are skeptical that GammaGraft can be used without any other wound coverings after the GammaGraft has dried on the wound. This is possible because GammaGraft has a natural keratin layer that acts as a vapor barrier for the wound. This allows for moist wound healing and a moist wound bed, even though the GammaGraft is dry.”

Stored at ambient temperature

“The Graftjacket Matrix provides a scaffold for host cell repopulation, revascularization and, ultimately, conversion to host tissue. Coupled with excellent tensile and suture retention strength, the biological characteristics of the Graftjacket Matrix make it an excellent scaffold to reinforce primary soft-tissue repairs throughout the body while eliminating morbidity associated with harvesting autograft.”

Stored at room temperature, 2-year shelf life.

• Superior suture retention strength.
• Flexible matrix for precise placement.
• Lower inflammatory response vs. competitors.
• Distributed as a frozen product.
• Sterility assurance level (SAL) 10-6.
• 5 year shelf life.
• Frozen storage.”

• “Intact extracellular matrix that promotes tissue remodeling.
• Superior safety profile-over 20,000 applications with no adverse reactions reported.”

“The Matrix HD graft provides a natural scaffold to support the body’s regenerative process.”

“Sterile–Terminally sterilized to a SAL of ^10–6. Validated viral inactivation.

Biocompatible: Preserved vascular channels. Preserved key components of the native matrix.”

“Convenient: Room temperature storage. Five year shelf life.

Simple, single-step rehydration.”

“Strong, pliable tissue conforms to wound topography. Amniotic tissue is naturally rich in growth factors to support the healing process, and provides an immune-privileged barrier to support the patient’s body in preventing inflammation and scar tissue generation. Available in a moist configuration (AlloWrap DS) or dry (AlloWrap Dry) designed for ease of handling in wound care placements.

Room temperature storage, with two-year shelf life, no need for expensive cryo freezer storage.”

“Maintains inherent growth factors and matrix proteins essential to wound healing and host tissue remodeling. Aseptic processing preserves tissue’s natural structure.

Ready, right out of the package. Can be used in the hydrated or dehydrated state. Shelf life of three years at ambient temperature. Conforms to anatomy and maintains surface contact.”

“The membrane forms a protective covering over the wound while providing the key components found in human amnion including an intact ECM, cytokines and other growth factors. It easily integrates into the wound and helps provide the optimal environment to repair, reconstruct and replace wound tissue.”

Room-temperature stable for 2 years

“Human collagen matrix. Contains growth factors that modulate inflammation, reduce scarring, and enhance healing. Versatile tissue form provides a scaffold for ingrowth in acute and chronic wounds. Terminally sterilized for enhanced patient safety. PURION® processed to provide an effective allograft with excellent handling characteristics.

5 year shelf life stored at ambient conditions.”

“Acts as a barrier membrane. Reduces scar tissue formation. Modulates inflammation. Enhances healing. Terminally sterilized for enhanced patient safety. PURION® processed to provide an effective allograft with excellent handling characteristics.

5 year shelf life stored at ambient conditions.”

“The liquid based suspension is especially suited to help repair wounds where membrane products might not be as effective (i.e. tunneling or deep wounds).”

Should be stored at -60°C or below.

“Artacent Wound is the only wound-specific amniotic patch that can be applied with either side facing the wound. Amniotic tissues are safe, natural biologic barriers, with native membranes supplying a wide array of growth factors. The unique design of Artacent Wound allows for easy manipulation and repositioning, making it a flexible, dependable option for a variety of wound covering applications.”

Dehydrated, storage at room temperature, shelf life greater than 2 years.

“BioDFactor® Viable Tissue Matrix is a cryopreserved allograft derived from the human placental tissues. It has been developed for use as a wound covering in the treatment of localized tissue defects or areas of inflammation. Placental tissues are a rich source of collagen, elastin, fibronectin, and growth factors to support tissue repair and regeneration. Additionally, amniotic tissue has anti-adhesive and anti-microbial properties important in the treatment of soft tissue injuries.”

Maintain the product at -65°C or colder until immediately prior to use, 2 year shelf life

Website does not list any specific benefits for chronic wounds.

Ambient temperature storage, terminally sterilized with a 5-year shelf life.

“Cellesta is a natural human tissue scaffold that protects and cushions, just as it does in utero. Made up of growth factors, hyaluronic acid, cytokines, amino acids, and extracellular matrix proteins, it makes an attractive wound material.”

Store at ambient temperature.

• Stored at ambient temperature with a 5-year shelf-life.
• Orientation stickers and notch in the upper left hand corner allow placement of the patch epithelial side up and stromal side down.
• E-Beam sterilization provides sterility assurance level (SAL) of 10-6.”

“Dermavest provides a scaffold to replace damaged or inadequate integumental tissue.”

Store at room temperature. 3-year shelf life.

“EpiCord provides a protective environment for the healing process. Provides a connective tissue matrix to replace or supplement damaged or inadequate integumental tissue.

5 year shelf life stored at ambient conditions.”

• “Acts as a barrier membrane.
• Reduces scar tissue formation.
• Modulates inflammation.
• Enhances healing.
• Terminally sterilized for enhanced patient safety.
• Purion processed to provide an effective allograft with excellent handling characteristics.
• 5 year shelf life stored at ambient conditions.”

• “FlowerAmnioPatch is a Ready-for-Surgery™, dual-layer amniotic membrane allograft with excellent handling characteristics.
• Safe, natural covering that improves wound healing.
• Reduces inflammation.
• Adhesion barrier.
• Reduces scarring at surgical site.
• Decreases post-operative pain.”
• Stored at room temperature.

“BioFix Amniotic Allografts are carefully processed using HydraTek® technology, a proprietary process designed to preserve the natural structure and biological properties of the tissue, to provide ideal graft handling, strength, and performance.”

“Features & Benefits:

• Omnidirectional Placement–Membranes can be implanted on either side to provide an effective covering and gliding surface over the tissue.
• Foundation for Regeneration–The Extracellular Matrix contains collagen and other fibrous proteins that provide a structural scaffold to support cellular migration. Naturally occurring growth factors, fibronectin, integrins, laminins, and hyaluronic acid play a key role in cell proliferation, differentiation, and adherence to the scaffold.”

• Off-the-Shelf Storage–BioFix Flow can be stored at an ambient temperature for 5 years.
• Reduces Inflammation, Scarring, and Pain–Amniotic tissues may reduce inflammation, fibrous tissue growth, and potential scar tissue formation.
• Flexible Application–BioFix Flow is ready to implant and precisely targets defects using a range of needle gauges for ease of implantation.”

• Able to completely fill irregular spaces or soft tissue voids resulting from trauma, surgery, or aging.
• Allows for cell adherence and growth during tissue repair.
• Consists of natural human structural and biochemical extracellular matrix components.
• Adapts to local mechanical forces.
• Provides structural support while maintaining elasticity.”

“The regenerative healing properties of Umbilical Cord and Amniotic Membrane delivered in a 1 mm thick allograft for superior handling and fixation, preserved using our patented Cryotek® process.”

Shelf life is two years from date of manufacture. Can be stored in a standard refrigerator or freezer at specified temperatures and specified times.

“Organogenesis’ proprietary BioLoc™ processing method results in less manipulation than other dehydrated amniotic allografts. This process preserves the native structure of the amnion and chorion membranes, and maintains the spongy/intermediate layer, which is an abundant source of proteoglycans, glycoproteins and hyaluronic acid. Through this process, NuShield is also optimized to provide excellent strength, flexibility, and handling.”

Five-year shelf life

• “Resorbable.
• Chorion free.
• Amnion membrane.
• Growth Factors.
• Cytokines.
• Amino Acids.
• Extracellular Matrix Proteins.
• Hyaluronic Acid.
• Available in a variety of sizes.
• Sterile.
• Room temperature (15° C to 30° C).”

• “Freeze-dried.
• Never delaminated.
• Preserves intermediate layer which contains hyaluronic acid and additional proteins.”

“WoundEx® Membrane Product Benefits:

Provides a native human placental BioActive® ECM, Various sizes minimize graft waste & cost, Adheres to wound bed without fixation, FastActing® Technology improves biologic response.”

Room temperature storage.

“Architect is the only ECM stabilized by the BriDGE® process which prevents premature degradation by the excess MMPs and other proteases found in chronic wounds. Because Architect® remains intact, its ECM healing properties remain intact, including:

Helping to deactivate the inflammatory phase (which results in a reduction of MMPs, elastase, and other proteases).

Helping to promote the proliferative/healing phase. Preserving cell signaling factors to trigger and accelerate healing.

Providing an intact, durable scaffold for uninterrupted support of cellular growth and regeneration of native tissue.”

Freeze dried, stored at room temperature, long shelf life (actual length not reported)

Bio-ConneKt Wound Matrix is a collagen-based wound dressing for the local management of moderately to heavily exuding wounds. It is composed of reconstituted type I collagen that is stabilized, sterilized to SAL 10^-6, and stored at room temperature.

Bio-ConneKt Wound Matrix is a sterile, conformable, and porous wound dressing made of reconstituted collagen derived from equine tendon. It is chemically crosslinked to provide resistance to enzymatic degradation. The dressing is provided sterile for single use only.

“Broad spectrum MMP reduction

• Advanced care accessible to all clinicians.
• Cost efficiency through weekly applications.”

15ºC/59ºF-40ºC/104ºF in a clean and dry area.

“Excellagen is a flowable, formulated homogenate of purified bovine Type I dermal collagen with collagen’s natural 3-dimensional fibrillar structure. Excelllagen promotes chemotaxis, cellular adhesion, migration and proliferation to stimulate granulation tissue formation. Excellagen is indicated for non-healing lower extremity ulcers in diabetic patients, and other dermal wounds and is intended for physician use during debridement procedures, which are used to promote and stimulate wound healing.”

Refrigerated 35-46°F (2-8°C) storage required

“EZ Derm can be used for partial thickness skin loss injuries. EZ Derm can also be used as a temporary cover, or test graft, prior to autografting and as a protective covering over meshed autografts. EZ Derm maintains a protected moist wound environment during the healing process and aids the natural healing of the wound. It assists in controlling early wound exudates and assist in restoring water vapour function and heat loss. EZ Derm allows reepithelialization and growth of granulation tissue and reduces pain and fluid loss. It is a protective barrier by physical means and provide protection of the wound.”

Stored at room temperature.

Helicoll reduces wound pain, accelerates the healing rate, reduces scarring, reduces hospital stay, and reduces treatment cost.

Shelf life of 3 years at room temperature.

“A single layer collagen matrix that supports a healing environment for wounds.”

Room temperature storage with a 24-month shelf life.

• Contain epithelial basement membrane.
• and numerous collagens.
• Non-crosslinked wound management scaffold.
• Complement standard of care.”

“The first-and-only wound matrix derived from porcine liver, Miroderm® retains an intact extracellular matrix with unique properties.”

Stored at room temperature.

No website is devoted to this product for treating chronic wounds.

Stored at room temperature with a shelf life of 36 months.

“The PriMatrix proprietary processing technology preserves the beneficial properties of the natural dermal collagen fibers and generates a tissue matrix free of contaminants and artificial chemical crosslinks. When applied to the patient’s wound PriMatrix rapidly fills with blood, binding both cells and growth factors. The enriched dermal collagen fibers support cellular repopulation and revascularization processes critical in wound healing.”

Store at room temperature.

“Our Puracol wound dressings (Puracol Plus, Puracol Plus Ag+ and Puracol Ultra Powder) promote natural healing with type I 100% native collagen. Our exclusive, gentle manufacturing technology preserves the collagen’s natural structure, resulting in dressings that provide more collagen to a wound for a longer period of time.”

“Native collagen wound dressings can be used to manage chronic wounds. The addition of collagen to the wound bed may reduce excess MMP activity to promote the wound healing cycle.”

“PuraPly AM utilizes a purified native collagen matrix embedded with the antimicrobial [PHMB], a broad spectrum antimicrobial. It is this combination of native collagen and PHMB that helps manage the reformation of biofilm while supporting healing across a wide variety of wound types, regardless of severity or duration.”

Stored in a clean, dry location at room temperature.

• “86% of patients experienced complete wound healing.
• Non-immunogenic.
• Easy to apply.
• Store at room temperature for up to 3 years.”

“Application of TheraSkin—a real human skin allograft—can replace damaged skin and can assist in healing most chronic wounds, even wounds that have not progressed for many months and have failed to heal with other therapies.”

“TheraSkin is a biologically active, cryopreserved human skin allograft, composed of living cells, fibroblasts and keratinocytes, and a fully developed extracellular matrix (ECM) in its epidermal and dermal layers. TheraSkin provides, upon application, a supply of growth factors/cytokines, and a robust collagen scaffold to jumpstart healing in a chronic wound.”