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Headline
Specialist and generic services for young people with anorexia nervosa achieve similar outcomes for a similar cost, despite patients in specialist services being typically more severely ill when diagnosed.
Abstract
Background:
Evidence suggests that investing in specialist eating disorders services for young people with anorexia nervosa could have important implications for the NHS, with the potential to improve health outcomes and reduce costs through reductions in the number and length of hospital admissions.
Objectives:
The primary objectives were to evaluate the costs and cost-effectiveness of alternative community-based models of service provision for young people with anorexia nervosa and to model the impact of potential changes to the provision of specialist services.
Design:
Observational surveillance study using the Child and Adolescent Psychiatry Surveillance System.
Setting:
Community-based secondary or tertiary child and adolescent mental health services (CAMHS) in the UK and the Republic of Ireland.
Participants:
A total of 298 young people aged 8–17 years in contact with CAMHS for a first episode of anorexia nervosa in accordance with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, diagnostic criteria.
Interventions:
Community-based specialist eating disorders services and generic CAMHS.
Main outcome measures:
Children’s Global Assessment Scale (CGAS) score (primary outcome) and percentage of median expected body mass index (BMI) for age and sex (%mBMI) (secondary outcome) were assessed at baseline and at 6 and 12 months.
Data sources:
Data were collected by clinicians from clinical records.
Results:
Total costs incurred by young people initially assessed in specialist eating disorders services were not significantly different from those incurred by young people initially assessed in generic CAMHS. However, adjustment for baseline covariates resulted in observed differences favouring specialist services (costs were lower, on average) because of the significantly poorer clinical status of the specialist group at baseline. At the 6-month follow-up, mean %mBMI was significantly higher in the specialist group, but no other significant differences in outcomes were evident. Cost-effectiveness analyses suggest that initial assessment in a specialist service has a higher probability of being cost-effective than initial assessment in generic CAMHS, as determined by CGAS score and %mBMI. However, no firm conclusion can be drawn without knowledge of society’s willingness to pay for improvements in these outcomes. Decision modelling did not support the hypothesis that changes to the provision of specialist services would generate savings for the NHS, with results suggesting that cost per 10-point improvement in CGAS score (improvement from one CGAS category to the next) varies little as the percentage of participants taking the specialist or generic pathway is varied.
Limitations:
Follow-up rates were lower than expected, but the sample was still larger than has been achieved to date in RCTs carried out in this population in the UK, and an exploration of the impact of missing cost and outcome data produced very similar results to those of the main analyses.
Conclusions:
The results of this study suggest that initial assessment in a specialist eating disorders service for young people with anorexia nervosa may have a higher probability of being cost-effective than initial assessment in generic CAMHS, although the associated uncertainty makes it hard to draw firm conclusions. Although costs and outcomes were similar, young people in specialist services were more severely ill at baseline, suggesting that specialist services were achieving larger clinical effectiveness gains without the need for additional expenditure. The results did not suggest that providing more specialist services would save money for the NHS, given similar costs and outcomes, so decisions about which service type to fund could be made with reference to other factors, such as the preferences of patients and carers.
Future work:
Data on measures of quality of life capable of generating quality-adjusted life-years are needed to confirm the cost-effectiveness of specialist services.
Trial registration:
Current Controlled Trials ISRCTN12676087.
Funding:
This project was funded by the National Institute for Health Research (NIHR) Health Services and Delivery Research programme and will be published in full in Health Services and Delivery Research; Vol. 7, No. 37. See the NIHR Journals Library website for further project information.
Contents
- Plain English summary
- Scientific summary
- Chapter 1. Introduction
- Chapter 2. Methods
- Study design
- Sampling
- Setting
- Procedures
- Inclusion and exclusion criteria
- Data
- Sample size
- Incidence of child and adolescent anorexia nervosa
- Classification of child and adolescent mental health services as specialist or generic
- Cost, effectiveness and cost-effectiveness analysis
- Decision-analytic modelling
- Ethics approvals and study registration
- Public and patient involvement
- Chapter 3. Results
- Chapter 4. Discussion
- Overview of the main results
- Cost-effectiveness of specialist versus generic services
- Impact of changes to the provision of specialist services
- Health service use and costs
- Outcomes
- Incidence of anorexia nervosa in young people aged 8–17 years
- Criteria for the classification of services as specialist
- Timing of the CostED study
- Strengths and limitations
- Future research
- Conclusion
- Acknowledgements
- References
- Appendix 1. Service use
- Appendix 2. Cost-effectiveness analysis: Delphi sensitivity analysis
- Glossary
- List of abbreviations
About the Series
Article history
The research reported in this issue of the journal was funded by the HS&DR programme or one of its preceding programmes as project number 11/1023/17. The contractual start date was in June 2013. The final report began editorial review in February 2018 and was accepted for publication in August 2018. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HS&DR editors and production house have tried to ensure the accuracy of the authors’ report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.
Declared competing interests of authors
Tamsin Ford is chairperson of the Child and Adolescent Psychiatry Surveillance Service that was used to run part of the study, which is an unpaid position (other than travel expenses). Kandarp Joshi reports grants from Sunovion Pharmaceuticals, Inc., outside the submitted work. He was principal investigator for the Aberdeen site for a Sunovion-sponsored multisite trial on the efficacy and safety of lurasidone in paediatric schizophrenia. Jonathan Kelly reports that Beat has contracts with some NHS trusts and clinical commissioning groups that provide and commission, respectively, community eating disorders services for children and young people. In these contracts, Beat works with the local services to deliver awareness-raising training for professionals and, in some cases, to offer peer coaching for carers. The funding Beat receives in return for its role in this project is not ‘on my behalf’. Beat is a co-applicant on another research project called ‘TRIANGLE’ (short title), which is also funded by the National Institute for Health Research. The funding Beat receives in return for its role in this project is not ‘on my behalf’. Beat is a co-applicant on another research project called ‘Mind the Gap’ (short title), which is funded by the Welsh Assembly Government and is investigating referral pathways from identification to specialist treatment for people with eating disorders (of all ages) in Wales.
Last reviewed: February 2018; Accepted: August 2018.
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