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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.

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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

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DILI Information Resources

Last Update: April 1, 2021.


  • Featured Resources
  • Monitoring Systems
  • Bibliographic
  • Registries and Research
  • Factual
  • Select Review Articles
  • Imaging
  • Promotional Brochure




Monitoring Systems

Registries and Research

Select Review Articles [Recent 4 Years]

Hey-Hadavi J, Seekins D, Palmer M, Coffey D, Caminis J, Abdullaev S, Patwardhan M, et al. Overview of causality assessment for drug-induced liver injury (DILI) in clinical trials. Drug Saf. 2021 Mar 16; Epub ahead of print. [PMC free article: PMC8184702] [PubMed: 33725335]
Devarbhavi H, Aithal G, Treeprasertsuk S, Takikawa H, Mao Y, Shasthry SM, Hamid S, Tan SS, et al. Asia Pacific Association of Study of Liver. Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines. Hepatol Int. 2021 Feb 27; Epub ahead of print. [PubMed: 33641080]
Liu A, Walter M, Wright P, Bartosik A, Dolciami D, Elbasir A, Yang H, Bender A. Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure. Biol Direct. 2021;16(1):6. [PMC free article: PMC7814730] [PubMed: 33461600]
Takemura A, Ito K. Nihon Yakurigaku Zasshi. 2020;155(6):401–5. [The trends in predicting drug-induced liver injury] Japanese. [PubMed: 33132258]
Apel K, Pütz K, Tolkach Y, Canbay A, Drebber U. Drug-induced liver injury – Stellenwert der Pathologie. Pathologe. 2020;41(5):457–70. [Drug-induced liver injury–significance of pathology] German. [PubMed: 32813127]
Low EXS, Zheng Q, Chan E, Lim SG. Drug induced liver injury: East versus West – a systematic review and meta-analysis. Clin Mol Hepatol. 2020;26(2):142–54. [PMC free article: PMC7160354] [PubMed: 31816676]
Gasmi B, Kleiner DE. Liver histology: diagnostic and prognostic features. Clin Liver Dis. 2020;24(1):61–74. [PMC free article: PMC6986808] [PubMed: 31753251]
Watkins PB. Quantitative systems toxicology approaches to understand and predict drug-induced liver injury. Clin Liver Dis. 2020;24(1):49–60. [PubMed: 31753250]
Thakkar S, Li T, Liu Z, Wu L, Roberts R, Tong W. Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity. Drug Discov Today. 2020;25(1):201–8. [PubMed: 31669330]
Andrade RJ, Robles-Díaz M. Diagnostic and prognostic assessment of suspected drug-induced liver injury in clinical practice. Liver Int. 2020;40(1):6–17. [PubMed: 31578817]
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, et al. Drug-induced liver injury. Nat Rev Dis Primers. 2019;5(1):58. [PubMed: 31439850]
Hoofnagle JH, Björnsson ES. Drug-induced liver injury – types and phenotypes. N Engl J Med. 2019;381(3):264–73. [PubMed: 31314970]
Uetrecht J. Mechanisms of idiosyncratic drug-induced liver injury. Adv Pharmacol. 2019;85:133–63. [PubMed: 31307585]
Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, et al. APASL ACLF Research Consortium (AARC) for APASL ACLF working Party. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int. 2019;13(4):353–90. Erratum in: Hepatol Int 2019; 13(6): 826-8. [PMC free article: PMC6728300] [PubMed: 31172417]
He S, Zhang C, Zhou P, Zhang X, Ye T, Wang R, Sun G, Sun X. Herb-induced liver injury: phylogenetic relationship, structure-toxicity relationship, and herb-ingredient network analysis. Int J Mol Sci. 2019;20(15):3633. [PMC free article: PMC6695972] [PubMed: 31349548]
McGill MR, Jaeschke H. Biomarkers of drug-induced liver injury. Adv Pharmacol. 2019;85:221–39. [PMC free article: PMC7351790] [PubMed: 31307588]
Real M, Barnhill MS, Higley C, Rosenberg J, Lewis JH. Drug-induced liver injury: highlights of the recent literature. Drug Saf. 2019;42(3):365–87. [PubMed: 30343418]
García-Cortés M, Ortega-Alonso A, Lucena MI, Andrade RJ., Spanish Group for the Study of Drug-Induced Liver Disease. (Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos GEHAM). Drug-induced liver injury: a safety review. Expert Opin Drug Saf. 2018;17(8):795–804. [PubMed: 30059261]
Roytman MM, Poerzgen P, Navarro V. Botanicals and Hepatotoxicity. Clin Pharmacol Ther. 2018;104(3):458–69. [PubMed: 29920648]
Ortega-Alonso A, Andrade RJ. Chronic liver injury induced by drugs and toxins. J Dig Dis. 2018;19(9):514–21. [PubMed: 29808546]
Kleiner DE. Recent advances in the histopathology of drug-induced liver injury. Surg Pathol Clin. 2018;11(2):297–311. [PMC free article: PMC5953206] [PubMed: 29751876]
Thakkar S, Chen M, Fang H, Liu Z, Roberts R, Tong W. The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury. Expert Rev Gastroenterol Hepatol. 2018;12(1):31–8. [PubMed: 28931315]
Brown AC. Liver toxicity related to herbs and dietary supplements: Online table of case reports. Part 2 of 5 series. Food Chem Toxicol. 2017;107:472–501. [PubMed: 27402097]
Navarro VJ, Khan I, Björnsson E, Seeff LB, Serrano J, Hoofnagle JH. Liver injury from herbal and dietary supplements. Hepatology. 2017;65(1):363–73. [PMC free article: PMC5502701] [PubMed: 27677775]

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