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Show detailsDefinition/Introduction
The German neurologist Johann Hoffman first postulated this sign. It was described by his assistant Hans Curschmann in 1911 and has become a standard part of the common neurologic exam.[1] The Hoffman sign is an involuntary flexion movement of the thumb and or index finger when the examiner flicks the fingernail of the middle finger down (see Image. Hoffmann Sign). The reflexive pathway causes the thumb to flex and adduct quickly. A positive Hoffman sign indicates an upper motor neuron lesion and corticospinal pathway dysfunction likely due to cervical cord compression. However, up to 3% of the population has been found to have a positive Hoffman without cord compression or upper motor neuron disease.[2]
Issues of Concern
While the Hoffman sign can help as a screening tool, it is not reliable as a stand-alone predictor of spinal cord compression. Degenerative cervical myelopathy is a spinal cord dysfunction that can lead to numbness, pain, imbalance, sensory loss, hyperreflexia, and urinary incontinence. Estimates are that nearly 1.6 per 100,000 have had surgical treatment for cervical myelopathy.[3] During a standard neurological exam, the Hoffman sign is common, and a positive sign can aid in the diagnosis. However, a 2018 systematic review, with level 1 evidence, on the utility of the Hoffman sign for the diagnosis of degenerative cervical myelopathy found insufficient data to support the use of the exam alone to confirm or refute a diagnosis of degenerative cervical myelopathy.[4] While the Hoffman sign can help as a screening tool, clinicians cannot rely on it as a stand-alone predictor of spinal cord compression.
Clinical Significance
The gold standard for diagnosing cervical myelopathy is magnetic resonance imaging (MRI). A 2015 study found that positive cord signal changes on MRI correlate with 67% of those with a positive Hoffman sign.[5] The Hoffman sign is not always indicative of pathological cord compression.[2] But when it is present with corresponding MRI images, it was shown that if the compression of the cervical cord was higher in the canal, it correlated with a higher incidence of a positive Hoffman sign.[1]
Nursing, Allied Health, and Interprofessional Team Interventions
As a standard part of neurological examination, all interprofessional healthcare team members should be familiar with the Hoffman sign and its clinical ramifications. This includes clinicians (including nurse practitioners and physician assistants) and nurses, plus physical therapists and chiropractors. It is an easy test to perform, and understanding the significance can help direct the patient to the clinical care they need (eg, via appropriate referrals and further testing) and improve outcomes. This requires open communication between all members of the healthcare team across professional disciplines.
![Hoffmann Sign](/books/NBK545156/bin/Kabir_Hoffmann__Sign.gif)
Figure
Hoffmann Sign. This diagram depicts a positive Hoffmann sign, a standard part of the common neurologic exam. Contributed by R Kabir, MD
References
- 1.
- Cao J, Liu Y, Wang Y, Zhao L, Wang W, Zhang M, Wang L. A Clinical Correlation Research of the Hoffmann Sign and Neurological Imaging Findings in Cervical Spinal Cord Compression. World Neurosurg. 2019 Aug;128:e782-e786. [PubMed: 31078802]
- 2.
- Annaswamy TM, Sakai T, Goetz LL, Pacheco FM, Ozarkar T. Reliability and repeatability of the Hoffmann sign. PM R. 2012 Jul;4(7):498-503. [PubMed: 22543037]
- 3.
- Davies BM, Mowforth OD, Smith EK, Kotter MR. Degenerative cervical myelopathy. BMJ. 2018 Feb 22;360:k186. [PMC free article: PMC6074604] [PubMed: 29472200]
- 4.
- Fogarty A, Lenza E, Gupta G, Jarzem P, Dasgupta K, Radhakrishna M. A Systematic Review of the Utility of the Hoffmann Sign for the Diagnosis of Degenerative Cervical Myelopathy. Spine (Phila Pa 1976). 2018 Dec 01;43(23):1664-1669. [PubMed: 29668564]
- 5.
- Nemani VM, Kim HJ, Piyaskulkaew C, Nguyen JT, Riew KD. Correlation of cord signal change with physical examination findings in patients with cervical myelopathy. Spine (Phila Pa 1976). 2015 Jan 01;40(1):6-10. [PubMed: 25341986]
Disclosure: Eric Whitney declares no relevant financial relationships with ineligible companies.
Disclosure: Sunil Munakomi declares no relevant financial relationships with ineligible companies.
- Cervical spinal cord compression and the Hoffmann sign.[Iowa Orthop J. 2001]Cervical spinal cord compression and the Hoffmann sign.Glaser JA, Curé JK, Bailey KL, Morrow DL. Iowa Orthop J. 2001; 21:49-52.
- A Clinical Correlation Research of the Hoffmann Sign and Neurological Imaging Findings in Cervical Spinal Cord Compression.[World Neurosurg. 2019]A Clinical Correlation Research of the Hoffmann Sign and Neurological Imaging Findings in Cervical Spinal Cord Compression.Cao J, Liu Y, Wang Y, Zhao L, Wang W, Zhang M, Wang L. World Neurosurg. 2019 Aug; 128:e782-e786. Epub 2019 May 9.
- Hoffmann sign: clinical correlation of neurological imaging findings in the cervical spine and brain.[Spine (Phila Pa 1976). 2015]Hoffmann sign: clinical correlation of neurological imaging findings in the cervical spine and brain.Grijalva RA, Hsu FP, Wycliffe ND, Tsao BE, Williams P, Akpolat YT, Cheng WK. Spine (Phila Pa 1976). 2015 Apr 1; 40(7):475-9.
- Review Hoffman-Tinel sign. The realities.[Phys Med Rehabil Clin N Am. 1998]Review Hoffman-Tinel sign. The realities.Alfonso MI, Dzwierzynski W. Phys Med Rehabil Clin N Am. 1998 Nov; 9(4):721-36, v.
- Review Manual dexterity: how does the cerebral cortex contribute?[Clin Exp Pharmacol Physiol. 1996]Review Manual dexterity: how does the cerebral cortex contribute?Darian-Smith I, Galea MP, Darian-Smith C. Clin Exp Pharmacol Physiol. 1996 Oct-Nov; 23(10-11):948-56.
- Hoffmann Sign - StatPearlsHoffmann Sign - StatPearls
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