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The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.
Contents
- The National Academies of SCIENCES • ENGINEERING • MEDICINE
- PLANNING COMMITTEE ON CARE, USE, AND WELFARE OF MARMOSETS AS ANIMAL MODELS FOR GENE EDITING–BASED BIOMEDICAL RESEARCH: A WORKSHOP
- ROUNDTABLE ON SCIENCE AND WELFARE IN LABORATORY ANIMAL USE
- INSTITUTE FOR LABORATORY ANIMAL RESEARCH
- Acknowledgments
- 1. Introduction
- 2. Context for the Use of Marmosets as Animal Models
- 3. Ethical Considerations
- 4. Current Research Applications
- 5. Marmoset Genomics and Genetic Diversity
- 6. Marmoset Supply and Availability
- 7. Marmoset Care and Management
- 8. Final Remarks
- Appendix A. Workshop Agenda
- Appendix B. Professional Biosketches
Suggested citation:
National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing–Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: https://doi.org/10.17226/25356.
Digital Object Identifier: https://doi.org/10.17226/25356
Additional copies of this publication are available from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.
Printed in the United States of America
Cover credit: Illustrations copyright 2013, Stephen D. Nash/IUCN SSC Primate Specialist Group. Used with permission.
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