Table 7, Critical Appraisal for Randomized Studies Using Cochrane Risk of Bias 2.0 Tool - Early Biologic Treatment versus Conventional Treatment for the Management of Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness

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Thompson W, Argáez C. Early Biologic Treatment versus Conventional Treatment for the Management of Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Feb 13.

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Early Biologic Treatment versus Conventional Treatment for the Management of Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness [Internet].

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Table 7Critical Appraisal for Randomized Studies Using Cochrane Risk of Bias 2.0 Tool¹²

Item	Khanna 2015¹⁵	D’Haens 2008¹⁴	Hoekman 2018¹⁶ (long-term follow-up from D’Haens 2008)
Risk of bias arising from randomization process	Some concerns	High	N/A
Deviations from intended interventions (effect of assignment to intervention)	Low	Low	N/A
Deviations from intended interventions (effect of adhering to intervention)	Some concerns	Some concerns	N/A
Missing outcome data	Some concerns	Low	Low
Measurement of the outcome	Some concerns	Some concerns	Low
Selection of reported results	Some concerns	High	High
Overall judgement	Some concerns	High	N/A

From: Early Biologic Treatment versus Conventional Treatment for the Management of Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness

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Thompson W, Argáez C. Early Biologic Treatment versus Conventional Treatment for the Management of Crohn’s Disease: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Feb 13. Table 7, Critical Appraisal for Randomized Studies Using Cochrane Risk of Bias 2.0 Tool.
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