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The Exocrine Pancreas
Stephen J. Pandol.
Author Information and AffiliationsABSTRACT
The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.
Contents
- Introduction
- Anatomy
- Pancreatic Embryology and Development
- Digestive Enzymes
- DIGESTIVE ENZYME SYNTHESIS AND TRANSPORT
- ENVIRONMENTAL AND GENETIC STRESSORS AND THE SECRETORY PATHWAY
- EXOCRINE PANCREATIC UPR ADAPTIVE RESPONSE
- ENVIRONMENTAL STRESS AND DISEASES OF THE EXOCRINE PANCREAS
- DIGESTIVE ENZYMES AND THEIR FUNCTIONS
- REGULATION OF DIGESTIVE ENZYME SYNTHESIS
- STIMULATION OF DIGESTIVE ENZYME SECRETION FROM THE ACINAR CELL
- Water and Ion Secretion from the Pancreatic Ductal System
- Regulation of Whole-Organ Pancreatic Secretion
- Measurement of Exocrine Pancreatic Secretion in Humans
- Clinical Application of Knowledge of Pancreatic Physiology
- Summary
- References
- NLM CatalogRelated NLM Catalog Entries
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- The Exocrine PancreasThe Exocrine Pancreas
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