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Clinical Review Report: abobotulinumtoxinA (Dysport Therapeutic): (Ipsen Biopharmaceuticals Canada Inc.): Indication: For the symptomatic treatment of lower-limb spasticity in pediatric patients 2 years of age and older [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Aug.

Cover of Clinical Review Report: abobotulinumtoxinA (Dysport Therapeutic)

Clinical Review Report: abobotulinumtoxinA (Dysport Therapeutic): (Ipsen Biopharmaceuticals Canada Inc.): Indication: For the symptomatic treatment of lower-limb spasticity in pediatric patients 2 years of age and older [Internet].

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Abbreviations

aboBoNTA

abobotulinumtoxinA

AE

adverse event

APT

all patients treated

BoNT

botulinum toxin

BoNTA

botulinum toxin A

CI

confidence interval

CP

cerebral palsy

DB

double-blind

EOS

end of study

EW

early withdrawal

FMQ

Leeds Functional Mobility Questionnaire

FPS

Faces Pain Scale

GAS

goal attainment scaling

GMFCS

Gross Motor Function Classification System

GMFM

Gross Motor Function Measure

GMFM-88

88-item Gross Motor Function Measure

GSC

gastrocnemius-soleus complex

ICC

intraclass correlation coefficient

ITC

indirect treatment comparison

ITT

intention-to-treat (population)

LLS

lower-limb spasticity

LS

least squares

MAS

Modified Ashworth Scale

OGS

Observational Gait Scale

onaBoNTA

onabotulinumtoxinA

PedsQL

Pediatric Quality of Life Inventory

PGA

Physician’s Global Assessment

RCT

randomized controlled trial

SAE

serious adverse event

SD

standard deviation

TEAE

treatment-emergent adverse event

TS

Tardieu Scale

U

units

ULS

upper-limb spasticity

VGA

Leeds Videographic Gait Assessment

WDAE

withdrawal due to adverse event

Copyright © 2018 Canadian Agency for Drugs and Technologies in Health.

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Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK540259
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