According to the Health Canada–approved indication, letermovir can be used for the prophylaxis of cytomegalovirus (CMV) infection in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT). Therefore, the objective of this review is to perform a systematic review of the beneficial and harmful effects of letermovir for the prophylaxis of CMV infection in adult CMV-seropositive recipients of an allogeneic HSCT.

Contents

• Abbreviations
• Executive Summary
  • Introduction
  • Results and Interpretation
  • Conclusions
• Introduction
  • Disease Prevalence and Incidence
  • Standards of Therapy
  • Drug
• Objectives and Methods
  • Objectives
  • Methods
• Results
  • Findings from the Literature
  • Included Studies
  • Critical Appraisal
  • Efficacy
  • Harms
• Discussion
  • Summary of Available Evidence
  • Interpretation of Results
• Conclusions
• Appendix 1. Patient Input Summary
• Appendix 2. Literature Search Strategy
• Appendix 3. Detailed Outcome Data
• Appendix 4. Validity of Outcome Measures
• Appendix 5. Cobas AmpliPrep/Cobas Taqman Cytomegalovirus Test
• Appendix 6. Correlation of Cytomegalovirus Viral Load and Clinical Outcomes
• References

Version: Final Clinical Review Report

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