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Hartmann KE, Fonnesbeck C, Surawicz T, et al. Management of Uterine Fibroids [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Dec. (Comparative Effectiveness Review, No. 195.)
Table I-3Systematic reviews of LNG-IUS (4 reviews)
| Author, Year | Intervention Category | Inclusion Criteria | Outcome(s) | Included Studies | Key Findings |
|---|---|---|---|---|---|
| Jiang W, Shen Q, Chen M, et al. 201411 | LNG-IUS | Premenopausal women with symptomatic uterine leiomyoma
Search dates: database inception through July 2013 | Fibroid and bleeding outcomes
Adverse effects | 11 studies; sample sizes ranging from 10 to 104 | Fibroid and bleeding outcomes
uterine volume: decreased menstrual blood loss: reduced hemoglobin: increased ferritin: increased hematocrit: increased leiomyoma volume: no change Adverse effects Device expulsion increased with leiomyoma size (larger than 3cm) not associated with leiomyoma location Irregular bleeding/spotting Observed at the beginning of the followup period and then decreased |
| Varma R, Sinha D, Gupta JK. 200612 | LNG-IUS | Observational and experimental studies of LNG-IUS
Search dates: 1996 to 2005 | Fibroid and bleeding outcomes | 3 RCTs; 7 observational studies for fibroids or fibroid related menorrhagia | Fibroid and bleeding outcomes
menstrual blood loss: decreased 84–90% hemoglobin: increased 2–3 g/dl fibroid size: inconsistent (decreased and no change) |
| Zapata LB, Whiteman MK, Tepper NK, et al. 201013 | LNG-IUS | Women with uterine fibroids
IUD (copper or levonorgestrelreleasing) use and uterine fibroids Search dates: database inception through June 2009 | Fibroid and bleeding outcomes
Expulsion rates | 11 studies | Fibroid and bleeding outcomes
menstrual blood loss: decreased (11 studies) among women using IUD hemoglobin, hematocrit and ferritin levels increased LNGIUD expulsion rates women with uterine fibroids: 0-20% (2 cohort studies, fair to poor quality; 6 noncomparative studies) women without uterine fibroids: 0 - 3% (2 cohort studies, fair to poor quality) |
| Sangkomka mhang US, Lumbiganon P, Laopaiboon M, et al. 201314 | LNG-IUS | Premenopausal women with uterine fibroids | Fibroid symptoms and characteristics
Quality of life Recurrence Adverse events Cost effectiveness | 3 RCTs with 187 women | No evidence of effectiveness of progestogens
Limited evidence of effectiveness of LNG-IUS Small sample sizes and few studies |
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