Tiotropium bromide Soft Mist Inhaler (Spiriva Respimat; Tio R 5) is a long-acting muscarinic antagonist (LAMA) indicated as a long-term, once-daily maintenance bronchodilator treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema, and for the reduction of exacerbations. The manufacturer is requesting a listing in line with the indication. Tio R 5 is available as a multi-use cartridge containing 60 2.5 mcg actuations. As the recommended dose of Tio R 5 is two inhalations of 2.5 mcg (5 mcg) once daily, each cartridge provides a 30-day supply.

Contents

• Abbreviations
• Summary
  • 1. Background
  • 2. Summary of the Economic Analysis Submitted by the Manufacturer
  • 3. Key Limitations
  • 4. Issues for Consideration
  • 5. Results and Conclusions
  • 6. Cost-Comparison Table
• APPENDIX 1. Reviewer Worksheets
• APPENDIX 2. Additional Cost Comparators
• References

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