The objective of this systematic review is to examine the beneficial and harmful effects of ocrelizumab treatment for the suppression of relapses and disease progression in adult patients with relapsing forms of multiple sclerosis (MS).

Contents

• Abbreviations
• Executive Summary
• Introduction
  • Disease Prevalence and Incidence
  • Standards of Therapy
  • Drug
• Objectives and Methods
  • Objectives
  • Methods
• Results
  • Findings from the Literature
  • Included Studies
  • Exposure to Study Treatments
  • Critical Appraisal
  • Efficacy
  • Harms
• Discussion
  • Summary of Available Evidence
  • Interpretation of Results
• Conclusions
• Appendix 1. Patient Input Summary
• Appendix 2. Literature Search Strategy
• Appendix 3. Detailed Outcome Data
• Appendix 4. Validity of Outcome Measures
• Appendix 5. Summary of Extension Study
• Appendix 6. Summary of Indirect Treatment Comparisons
• References

Version: 1.0

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