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Age, sex, race, or other demographic risk factors?

Coronary disease risk factors, diabetes, or other comorbid disease?

Angiographic-specific factors including, but not limited to, the number of diseased vessels amenable to bypass or stenting, vessel territory of stenoses (e.g., left main or anterior descending coronary arteries, right coronary artery, circumflex coronary artery), diffuse vs. focal stenoses, left ventricular function, or prior revascularization procedures?

CABG-specific factors including, but not limited to, cardiopulmonary bypass mode (normothermic vs. hypothermic), type of cardioplegia used (blood vs. crystalloid), or use of saphenous vein grafts, single or bilateral internal mammary artery grafts, or other types of bypass grafts?

Clinical presentation (e.g., stable angina or unstable angina based on New York Heart Association functional class I–IV, acute coronary syndrome, cardiogenic shock, acute myocardial infarction with or without ST elevation, or silent ischemia)?

Adjunctive medical therapies, such as short-term intravenous or oral antiplatelet drugs, or long-term use of oral antiplatelet drugs?

Process characteristics such as provider volume, hospital volume, and setting (e.g., academic vs. community)?

Prior PCI or CABG revascularization procedures?

Do medications differ in their efficacy and effectiveness in treating the depressive episode?

Do medications differ in their efficacy and effectiveness in treating the accompanying symptoms?

Elderly or very elderly patients;

Other demographic groups (defined by age, ethnic or racial groups, and sex);

Patients with medical comorbidities (e.g., ischemic heart disease, cancer);

Patients with psychiatric and behavioral comorbidities (e.g., substance abuse disorders); and

Patients taking other medications