Figure 3.3. Proposed series of events in the process of STIM1 activation, based on the current research findings.

Figure 3.3

Proposed series of events in the process of STIM1 activation, based on the current research findings. Left panel shows a resting state STIM1 that undergoes at least the five steps listed in the figure, resulting in an active form of the protein that is proficient in ORAI1 binding (right panel). Domain organization is the same as in Figure 3.1. Positions of the D76 and L251 are marked. Only regions corresponding to STIM1 aa1-450 are depicted for clarity.

From: Chapter 3, Signaling ER Store Depletion to Plasma Membrane Orai Channels

Cover of Calcium Entry Channels in Non-Excitable Cells
Calcium Entry Channels in Non-Excitable Cells.
Kozak JA, Putney JW Jr., editors.
Boca Raton (FL): CRC Press/Taylor & Francis; 2018.
© 2017 by Taylor & Francis Group, LLC.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.