NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Excerpt
This book covers many aspects of the biology of NMDARs: their role in controlling structure and function of synapses and neurons during early development; how overstimulation of NMDARs results in excitotoxicity and contributes to several progressive brain disorders, including Huntington’s disease; the newly discovered and intriguing interactions of NMDARs and dopamine receptors that mediate reward in the central nervous system; the role of NMDARs in alcohol dependence and the promise of NMDAR-based therapeutics for treating alcoholism; how functional expression is controlled at the level of gene transcription by several families of transcription factors; how NMDAR activation regulates local synaptic protein synthesis required for long-term changes in synaptic strength; the modulation of NMDAR function by signaling cascades cumulating in activation of protein kinases and phosphatases; the importance of cellular mechanisms underlying trafficking and targeting of NMDAR protein for many of its physiological functions; how NMDAR-mediated calcium signaling in dendritic spines controls synaptic efficacy and spine morphology; the roles NMDARs play in different temporal phases of memory formation in Drosophila; the extracellular modulation of NMDARs by polyamines, subunit-specific inhibitors, zinc ions, and pH, and the structural bases for their effects; a detailed description of NMDAR pharmacology, structure–activity relationships of agonists and antagonists, and roads to therapeutic drug design; the physiological roles played by NMDARs and their molecular structures; NMDAR activation mechanisms and the therapeutic potential of allosteric modulators; and the novel role of presynaptically localized NMDARs in controlling synaptic plasticity.
Contents
- Series Preface
- Preface
- About the Editor
- Contributors
- 1. NMDA Receptors and Brain DevelopmentRebecca C. Ewald and Hollis T. Cline.
- 2. NMDA Receptors and Huntington’s DiseaseHerman B. Fernandes and Lynn A. Raymond.
- 2.1 HUNTINGTON’S DISEASE
- 2.2 MODEL SYSTEMS FOR STUDY OF NMDA RECEPTOR FUNCTION IN HD
- 2.3 EXCITOTOXICITY HYPOTHESIS IN HD PATHOGENESIS
- 2.4 DOWNSTREAM CONSEQUENCES OF NMDA RECEPTOR ACTIVATION IN CELLS EXPRESSING MHTT
- 2.5 ALTERATIONS OF NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION AND PLASTICITY IN HD
- 2.6 POSSIBLE MECHANISMS FOR MODULATION OF NMDA RECEPTOR FUNCTION BY MHTT
- 2.7 SUMMARY
- REFERENCES
- 3. NMDA and Dopamine: Diverse Mechanisms Applied to Interacting Receptor SystemsCarlos Cepeda, Véronique M. André, Emily L. Jocoy, and Michael S. Levine.
- 3.1 INTRODUCTION
- 3.2 CLASSIFICATION AND MORPHOLOGICAL BASIS FOR INTERACTIONS AMONG GLUTAMATE AND DA RECEPTOR SUBTYPES
- 3.3 DA AND D1 RECEPTOR ENHANCEMENT OF NMDA RECEPTOR-MEDIATED RESPONSES
- 3.4 RECIPROCAL D1–NMDA RECEPTOR INTERACTIONS
- 3.5 TOPOGRAPHIC AND TEMPORAL ASPECTS OF D1–NMDA OCCURS RECEPTOR INTERACTIONS
- 3.6 REDUCTION OF NMDA RECEPTOR-MEDIATED RESPONSES BY DA OCCURS VIA D2 RECEPTORS
- 3.7 GENETIC MANIPULATIONS OF DA–NMDA RECEPTOR INTERACTIONS
- 3.8 FUNCTIONAL RELEVANCE OF DA–NMDA RECEPTOR INTERACTIONS
- 3.9 CONCLUSIONS
- REFERENCES
- 4. The NMDA Receptor and Alcohol AddictionDorit Ron and Jun Wang.
- 4.1 INTRODUCTION
- 4.2 ACUTE ETHANOL INHIBITION OF NMDA RECEPTOR FUNCTION
- 4.3 FACILITATION OF NMDA RECEPTOR FUNCTION BY ETHANOL
- 4.4 PHYSIOLOGICAL IMPLICATIONS OF MODULATION OF NMDA RECEPTOR FUNCTION BY ETHANOL
- 4.5 NMDA RECEPTORS AND BEHAVIORS ASSOCIATED WITH ETHANOL EXPOSURE
- 4.6 MODULATORS OF NMDA RECEPTOR FUNCTION AND TREATMENT OF ALCOHOL ABUSE AND DEPENDENCE
- REFERENCES
- 5. Transcriptional Regulation of NMDA Receptor ExpressionGuang Bai and Peter W. Hoffman.
- 6. NMDA Receptors and Translational ControlCharles A. Hoeffer and Eric Klann.
- 6.1 INTRODUCTION
- 6.2 OVERVIEW OF TRANSLATION
- 6.3 THREE STAGES OF TRANSLATION
- 6.4 RNA BINDING PROTEINS AND mRNA LOCALIZATION
- 6.5 ADMINISTERING TRANSLATION: NMDA RECEPTOR-DEPENDENT SIGNALING TO TRANSLATIONAL MACHINERY
- 6.6 NMDA RECEPTORS AND REGULATION OF TRANSLATIONAL SUBSTRATES
- 6.7 CONCLUDING THOUGHTS
- REFERENCES
- 7. Regulation of NMDA Receptors by Kinases and PhosphatasesMichael W. Salter, Yina Dong, Lorraine V. Kalia, Xue Jun Liu, and Graham Pitcher.
- 7.1 INTRODUCTION
- 7.2 NMDA RECEPTOR REGULATION BY SERINE AND THREONINE KINASES AND PHOSPHATASES
- 7.3 REGULATION OF NMDA RECEPTORS BY PROTEIN TYROSINE KINASES AND PHOSPHATASES
- 7.4 NMDA RECEPTOR PHOSPHORYLATION IN SYNAPTIC PLASTICITY
- 7.5 NMDA RECEPTOR PHOSPHORYLATION IN CENTRAL NERVOUS SYSTEM PATHOLOGY
- 7.6 CONCLUSIONS
- REFERENCES
- 8. Trafficking and Targeting of NMDA ReceptorsRonald S. Petralia, Rana A. Al-Hallaq, and Robert J. Wenthold.
- 9. NMDA Receptor-Mediated Calcium Transients in Dendritic SpinesBrenda L. Bloodgood and Bernardo L. Sabatini.
- 9.1 Introduction
- 9.2 SUBUNIT DEPENDENCE Of NMDA RECEPTOR-MEDIATED CALCIUM INFLUX
- 9.3 PHOSPHORYLATION-DEPENDENT REGULATION OF NMDA RECEPTOR-DEPENDENT CALCIUM ENTRY
- 9.4 VOLTAGE-DEPENDENT REGULATION OF SYNAPTICALLY EVOKED CALCIUM INFLUX
- 9.5 POSSIBLE EFFECTS OF COMPARTMENTALIZED ELECTRICAL SIGNALING ON NMDA RECEPTORS
- 9.6 IMPACT OF SPINE MORPHOLOGY ON CALCIUM SIGNALING IN DENDRITIC SPINES
- 9.7 CONCLUSION
- REFERENCES
- 10. NMDA Receptors in DrosophilaShouzhen Xia and Ann-Shyn Chiang.
- 10.1 INTRODUCTION
- 10.2 NMDA RECEPTOR HOMOLOGUES IN DROSOPHILA
- 10.3 FUNCTIONAL EXPRESSION OF FLY NMDA RECEPTORS
- 10.4 EXPRESSION OF FLY NMDA RECEPTORS IN ADULT BRAIN
- 10.5 NMDA RECEPTOR-DEPENDENT LEARNING AND LONG-TERM MEMORY CONSOLIDATION
- 10.6 LOCALIZATION OF NMDA RECEPTOR-DEPENDENT MEMORIES
- 10.7 NMDA RECEPTORS IN OTHER INVERTEBRATES
- 10.8 SUMMARY
- REFERENCES
- 11. Extracellular Modulation of NMDA ReceptorsKeith Williams.
- 11.1 INTRODUCTION
- 11.2 POLYAMINES
- 11.3 STRUCTURES OF NMDA RECEPTOR SUBUNITS AND RELEVANCE TO THE POLYAMINE SITE
- 11.4 IFENPRODIL
- 11.5 STRUCTURES OF NMDA RECEPTOR SUBUNITS AND RELEVANCE TO THE IFENPRODIL SITE
- 11.6 ZINC IONS
- 11.7 STRUCTURES OF NMDA RECEPTOR SUBUNITS AND RELEVANCE TO THE ZN2+ SITE
- 11.8 PROTONS AND EXTRACELLULAR pH
- 11.9 WHITHER NEXT?
- REFERENCES
- 12. Pharmacology of NMDA ReceptorsDaniel T. Monaghan and David E. Jane.
- 12.1 INTRODUCTION
- 12.2 PHARMACOLOGY OF THE NR2 GLUTAMATE BINDING SITE
- 12.3 PHARMACOLOGY OF GLYCINE BINDING SITE ON NR1
- 12.4 PHARMACOLOGY OF GLYCINE BINDING SITE ON NR3
- 12.5 ALLOSTERIC MODULATORY SITES ON NMDA Receptors
- 12.6 ZINC
- 12.7 UNCOMPETITIVE ANTAGONISTS (CHANNEL BLOCKERS)
- 12.8 CONCLUDING REMARKS
- REFERENCES
- 13. Activation Mechanisms of the NMDA ReceptorMarie L. Blanke and Antonius M.J. VanDongen.
- 14. Presynaptic NMDA ReceptorsIan C. Duguid and Trevor G. Smart.
Series editors: Sidney A Simon and Miguel AL Nicolelis
This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint.
- NLM CatalogRelated NLM Catalog Entries
- Review Activation Mechanisms of the NMDA Receptor.[Biology of the NMDA Receptor. ...]Review Activation Mechanisms of the NMDA Receptor.Blanke ML, VanDongen AMJ. Biology of the NMDA Receptor. 2009
- Review Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects.[Brain Res Bull. 2013]Review Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects.Vizi ES, Kisfali M, Lőrincz T. Brain Res Bull. 2013 Apr; 93:32-8. Epub 2012 Oct 23.
- Review Regulation of NMDA Receptors by Kinases and Phosphatases.[Biology of the NMDA Receptor. ...]Review Regulation of NMDA Receptors by Kinases and Phosphatases.Salter MW, Dong Y, Kalia LV, Liu XJ, Pitcher G. Biology of the NMDA Receptor. 2009
- Review NMDA Receptors in Drosophila.[Biology of the NMDA Receptor. ...]Review NMDA Receptors in Drosophila.Xia S, Chiang AS. Biology of the NMDA Receptor. 2009
- Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.[FASEB J. 2008]Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.Léveillé F, El Gaamouch F, Gouix E, Lecocq M, Lobner D, Nicole O, Buisson A. FASEB J. 2008 Dec; 22(12):4258-71. Epub 2008 Aug 18.
- Biology of the NMDA ReceptorBiology of the NMDA Receptor
Your browsing activity is empty.
Activity recording is turned off.
See more...