On December 5, 2017, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop titled Nutrigenomics and the Future of Nutrition in Washington, DC, to review current knowledge in the field of nutrigenomics as it relates to nutrition. Workshop participants explored the influence of genetic and epigenetic expression on nutritional status and the potential impact of personalized nutrition on health maintenance and chronic disease prevention. This publication summarizes the presentations and discussions from the workshop.

Contents

• The National Academies of SCIENCES • ENGINEERING • MEDICINE
• PLANNING COMMITTEE FOR A WORKSHOP ON NUTRIGENOMICS AND THE FUTURE OF NUTRITION
• FOOD FORUM (DECEMBER 2017)
• Reviewers
• 1. Introduction
  • SETTING THE STAGE: INTRODUCTION AND OVERVIEW
  • ORGANIZATION OF THIS PROCEEDINGS
• 2. Nutrigenomics and Chronic Disease Endpoints
  • GENOTYPES AND DISEASE RISK: WHAT IS CURRENTLY KNOWN ABOUT NUTRITION AND EPIGENETICS?
  • MITOCHONDRIAL GENETICS AND DISEASE RISK: EXPLORING CURRENT EVIDENCE
• 3. Personalized Nutrition in the Real World
  • EXPLORING PERSONAL, DENSE, DYNAMIC DATA CLOUDS AND THE FUTURE OF PERSONALIZED MEDICINE
  • SICKLE CELL DISEASE: AN ARGININE DEFICIENCY SYNDROME WITH DISTINCTIVE NUTRITIONAL REQUIREMENTS
  • PERSONALIZED NUTRITION IN THE REAL WORLD: WHERE DO WE STAND?
  • IS GENETIC TESTING FOR PERSONALIZED NUTRITION READY FOR PRIME TIME?
  • DISCUSSION
• 4. Nutrigenomics Applications: Dietary Guidance and Food Product Development
  • NUTRIENT REQUIREMENTS AS COMPLEX TRAITS: WHAT CONSUMERS NEED TO KNOW
  • GENE-GUIDED NUTRITION INTERVENTIONS
  • DISCUSSION
• 5. Nutrigenomics: Regulatory, Ethical, and Science Policy Considerations
  • SCIENTIFIC BASIS OF GENETICALLY PERSONALIZED NUTRITION: ETHICAL IMPLICATIONS OF METHODOLOGICAL LIMITATIONS
  • VETTING PERSONALIZED AND GENOMICALLY GUIDED NUTRITION: ISSUES AND STRATEGIES
  • POTENTIAL REGULATORY POLICY CONSIDERATIONS PRESENTED BY NUTRIGENOMICS IN THE COMMERCIAL CONTEXT
  • DISCUSSION
• 6. Rethinking the Relationship Between Diet and Health: Can Nutrigenomics Help?
  • THE USEFULNESS OF THE PRECISION MEDICINE PARADIGM IN NUTRITION
  • BEHAVIORAL ASPECTS OF NUTRIGENOMICS
  • WHY THE FOCUS ON GENETICS IN THIS ERA OF DATA INTEGRATION?
  • THE RELEVANCE OF NUTRIGENOMICS TO LOW-INCOME POPULATIONS
  • TRUST—AND DISTRUST—IN NUTRIGENOMICS
  • THE RELEVANCE OF AGRICULTURE TO NUTRIGENOMICS
• References
• APPENDIXES
  • A. Workshop Agenda
  • B. Acronyms and Abbreviations
  • C. Speaker and Facilitator Biographies

Rapporteur: Leslie Pray.

Suggested citation:

National Academies of Sciences, Engineering, and Medicine. 2018. Nutrigenomics and the future of nutrition: Proceedings of a workshop. Washington, DC: The National Academies Press. doi: https://doi.org/10.17226/25147.