Table 3, SAR Analysis for Selective κ–opioid receptor agonist for the Bisamide Scaffold - Probe Reports from the NIH Molecular Libraries Program

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SAR Analysis for KOR Selective Scaffolds (Medicinal Chemistry & Cheminformatics Analysis)										Potency (µM) Ave. ± S.E.M. (n = replicates) n value in column refers to KOR DRx replicates
#	CID	SID	BCCG MLS-	^*	R1	R2	R3	X	R4	N	KOR DRx	KOR HCS (n=2)	MOR HCS (n=2)	DOR HCS (n=2)
1	5236771	87218782	0254632	P	C₆H₁₁	C₅H₁₀		S	2-pyridyl	3	0.12 ±0.01	<0.06	>32	>32
2	4014737	87218783	0211381	P	C₆H₁₁	C₅H₁₀		S	2-pyrazinyl	3	0.44 ±0.06	0.14	>32	>32
3	3950926	87218781	0075520	P	C₆H₁₁	C₅H₁₀		O	2-pyridyl	3	0.82 ±0.04	0.13	>32	>32
4	1282817	87218798	0425703	P	p-Br-C₆H₄	C₅H₁₀		O	2-pyridyl	3	0.42 ±0.02	0.10	>32	>32
5	4579040	87218797	0079438	P	C₅H₉	C₅H₁₀		O	2-pyrazinyl	3	>10	>32	>32	>32
6	1297443	87218767	0024680	P	2,6-dimethyl- C₆H₄	C₄H₈		O	2-pyridyl	3	4.05 ±0.10	1.11	>32	>32
7	3950572	87218780	0237946	P	C₅H₉	Me	Et	S	2-pyridyl	3	2.07 ±0.17	0.81	>32	>32
8	3242935	87218796	0007493	P	C₆H₁₁	Me	Et	O	2-pyrazinyl	3	3.71 ±0.19	1.36	>32	>32
9	3964693	87218795	0080731	P	C₆H₁₁	Me	Et	O	2-pyridyl	3	0.65 ±0.03	0.17	>32	>32
10	1458208	85787073	0435478	S	C₆H₁₁	H	H	S	2-pyridyl	2	>20	ND	ND	ND
11	44483222	85787075	0435480	S	C₆H₁₁	H	H	S	3-pyridyl	2	>20	ND	ND	ND
12	44483224	85787074	0435479	S	C₇H₁₃	H	H	S	2-pyridyl	2	>20	ND	ND	ND
13	44483221	85787077	0435482	S	C₇H₁₃	H	H	S	3-pyridyl	2	>20	ND	ND	ND
14	44483223	85787076	0435481	S	MeO^**	H	H	S	3-pyridyl	2	>20	ND	ND	ND

Cite this Page
Hedrick MP, Gosalia P, Frankowski K, et al. Selective KOP Receptor Agonists: Probe 1 & Probe 2. 2010 Feb 28 [Updated 2010 Oct 4]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Table 3, SAR Analysis for Selective κ–opioid receptor agonist for the Bisamide Scaffold.
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Table 3, SAR Analysis for Selective κ–opioid receptor agonist for the Bisamide S...
Table 3, SAR Analysis for Selective κ–opioid receptor agonist for the Bisamide Scaffold - Probe Reports from the NIH Molecular Libraries Program

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