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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Table 5Receptor Paneling of KOP agonist [ML140] CID3342390 through the PDSP
| Receptor | Ki (nM) |
|---|---|
| 5ht1a | |
| 5ht1b | |
| 5ht1d | |
| 5ht1e | |
| 5ht2a | |
| 5ht2b | 592 |
| 5ht2c | |
| 5ht3 | |
| 5ht5a | 5,442 |
| 5ht6 | |
| 5ht7 | 1,990 |
| Alpha1A | |
| Alpha1B | |
| Alpha1D | |
| Alpha2A | |
| Alpha2B | 1,451 |
| Alpha2C | 957 |
| Beta1 | |
| Beta2 | |
| Beta3 | |
| BZP Rat Brain Site | |
| D1 | |
| D2 | |
| D3 | 1,234 |
| D4 | |
| D5 | |
| DAT | |
| DOR | 1,088 |
| H1 | |
| H2 | 4,162 |
| H3 | |
| H4 | |
| KOR | 40.3 |
| M1 | |
| M2 | |
| M3 | |
| M4 | |
| M5 | 310.6 |
| MOR | 305.6 |
| NET | |
| SERT | |
| Sigma 1 |
- Green: Ki > 10,000 or 1ary screen missed
- Orange: 2ndary assay pending
- Review Selective KOP Receptor Agonists: Probe 1 & Probe 2.[Probe Reports from the NIH Mol...]Review Selective KOP Receptor Agonists: Probe 1 & Probe 2.Hedrick MP, Gosalia P, Frankowski K, Shi S, Prisinzano TE, Schoenen F, Aubé J, Su Y, Vasile S, Sergienko E, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Review Antagonist for the Kappa Opioid Receptor.[Probe Reports from the NIH Mol...]Review Antagonist for the Kappa Opioid Receptor.Hedrick MP, Gosalia P, Li K, Frankowski KJ, Shi S, Prisinzano TE, Schoenen F, Aubé J, Su Y, Stonich D, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Noribogaine is a G-protein biased κ-opioid receptor agonist.[Neuropharmacology. 2015]Noribogaine is a G-protein biased κ-opioid receptor agonist.Maillet EL, Milon N, Heghinian MD, Fishback J, Schürer SC, Garamszegi N, Mash DC. Neuropharmacology. 2015 Dec; 99:675-88. Epub 2015 Aug 21.
- Species differences in the effects of the κ-opioid receptor antagonist zyklophin.[Alcohol. 2016]Species differences in the effects of the κ-opioid receptor antagonist zyklophin.Sirohi S, Aldrich JV, Walker BM. Alcohol. 2016 Mar; 51:43-9. Epub 2016 Jan 29.
- Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.[Eur J Pharmacol. 2016]Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.Huang P, Tunis J, Parry C, Tallarida R, Liu-Chen LY. Eur J Pharmacol. 2016 Jun 15; 781:53-9. Epub 2016 Apr 1.
- Table 5, Receptor Paneling of KOP agonist [ML140] CID3342390 through the PDSP - ...Table 5, Receptor Paneling of KOP agonist [ML140] CID3342390 through the PDSP - Probe Reports from the NIH Molecular Libraries Program
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