U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

Cover of Drugs and Lactation Database (LactMed®)

Drugs and Lactation Database (LactMed®) [Internet].

Show details


Last Revision: October 18, 2021.

Estimated reading time: 1 minute

CASRN: 120279-96-1

image 135049468 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Limited experience with the use of ophthalmic dorzolamide indicate that it is unlikely to adversely affect the breastfed infant.[1] French guidelines recommend ophthalmic carbonic anhydrase inhibitor drops as a preferred therapy for glaucoma during breastfeeding.[2] To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A newborn infant was breastfed during maternal therapy with various combinations of ocular timolol, dipivifrin, dorzolamide, brimonidine and several doses of acetazolamide. Ultimately, the mother was treated with timolol gel-forming solution 0.5% and dorzolamide 2% drops. The drugs were given immediately following breastfeeding with punctal occlusion and no apnea or bradycardia was observed in the infant.[3]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Belkin A, Chen T, DeOliveria AR, et al. A practical guide to the pregnant and breastfeeding patient with glaucoma. Ophthalmol Glaucoma. 2020;3:79–89. [PubMed: 32672600]
Blumen-Ohana E, Sellem E. J Fr Ophtalmol. 2020;43:63–6. [Pregnancy & glaucoma: SFO-SFG recommendations] [PubMed: 31813552]
Johnson SM, Martinez M, Freedman S. Management of glaucoma in pregnancy and lactation. Surv Ophthalmol. 2001;45:449–54. [PubMed: 11274697]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Antiglaucoma Agents

Carbonic Anhydrase Inhibitors

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501900PMID: 30000960


Related information

Similar articles in PubMed

  • Review Brinzolamide.[Drugs and Lactation Database (...]
    Review Brinzolamide.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Brimonidine.[Drugs and Lactation Database (...]
    Review Brimonidine.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Levobunolol.[Drugs and Lactation Database (...]
    Review Levobunolol.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Ketotifen.[Drugs and Lactation Database (...]
    Review Ketotifen.
    . Drugs and Lactation Database (LactMed®). 2006
  • Review Loteprednol.[Drugs and Lactation Database (...]
    Review Loteprednol.
    . Drugs and Lactation Database (LactMed®). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...