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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 159519-65-0
Drug Levels and Effects
Summary of Use during Lactation
No published information is available on the use of enfuvirtide during breastfeeding. Enfuvirtide is not a recommended agent during breastfeeding.[1,2] In the US and other countries where access to clean water and affordable replacement feeding are available, it is recommended that mothers living with HIV not breastfeed their infants to avoid postnatal transmission of HIV-1 infection. Achieving and maintaining viral suppression with antiretroviral therapy decreases breastfeeding transmission risk to less than 1%, but not zero. Individuals with HIV who are on antiretroviral therapy with a sustained undetectable viral load and who choose to breastfeed should be supported in this decision.[3]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- AIDSinfo. Panel on treatment of pregnant women with HIV infection and prevention of perinatal transmission. Recommendations for use of antiretroviral drugs in transmission in the United States, 2018: Counseling and management of women living with HIV who breastfeed.
- 2.
- World Health Organization. HIV and infant feeding: Update. 2007. http://whqlibdoc
.who .int/publications/2007 /9789241595964_eng.pdf. - 3.
- Department of Health and Human Services. Recommendations for the use of antiretroviral drugs during pregnancy and interventions to reduce perinatal HIV transmission in the United States. Infant feeding for individuals with HIV in the United States. 2023 https:
//clinicalinfohivgov /en/guidelines /perinatal/infant-feeding-individuals-hiv-united-states?view=full.
Substance Identification
Substance Name
Enfuvirtide
CAS Registry Number
159519-65-0
Drug Class
Breast Feeding
Milk, Human
Anti-Infective Agents
Anti-HIV Agents
Antiviral Agents
Anti-Retroviral Agents
HIV Fusion Inhibitors
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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