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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 124-43-6
Drug Levels and Effects
Summary of Use during Lactation
Carbamide (urea) peroxide has not been studied during breastfeeding. It is unlikely that carbamide peroxide found in ear drops or teeth whiteners is absorbed into the bloodstream. However, if any carbamide peroxide were absorbed, it would be broken down to urea and hydrogen peroxide, both of which are found normally in human milk.[1,2] If carbamide peroxide is used by the mother according to directions, it is not a reason to discontinue breastfeeding and no special precautions are required.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Clark RM, Ross SA, Hill DW, et al. Within-day variation of taurine and other nitrogen substances in human milk. J Dairy Sci. 1987;70:776–80. [PubMed: 3584613]
- 2.
- Al-Kerwi EA, Al-Hashimi AH, Salman AM. Mother's milk and hydrogen peroxide. Asia Pac J Clin Nutr. 2005;14:428–31. [PubMed: 16326651]
Substance Identification
Substance Name
Carbamide Peroxide
CAS Registry Number
124-43-6
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Ear drops for the removal of ear wax.[Cochrane Database Syst Rev. 2018]Ear drops for the removal of ear wax.Aaron K, Cooper TE, Warner L, Burton MJ. Cochrane Database Syst Rev. 2018 Jul 25; 7(7):CD012171. Epub 2018 Jul 25.
- Ear drops for the removal of ear wax.[Cochrane Database Syst Rev. 2003]Ear drops for the removal of ear wax.Burton MJ, Dorée CJ. Cochrane Database Syst Rev. 2003; (3):CD004400.
- Topical antiseptics for chronic suppurative otitis media.[Cochrane Database Syst Rev. 2025]Topical antiseptics for chronic suppurative otitis media.Head K, Chong LY, Bhutta MF, Daw J, Veselinović T, Morris PS, Vijayasekaran S, Schilder AG, Brennan-Jones CG. Cochrane Database Syst Rev. 2025 Jun 9; 6(6):CD013055. Epub 2025 Jun 9.
- Interventions for acute otitis externa.[Cochrane Database Syst Rev. 2010]Interventions for acute otitis externa.Kaushik V, Malik T, Saeed SR. Cochrane Database Syst Rev. 2010 Jan 20; 2010(1):CD004740. Epub 2010 Jan 20.
- Systemic antibiotics for chronic suppurative otitis media.[Cochrane Database Syst Rev. 2021]Systemic antibiotics for chronic suppurative otitis media.Chong LY, Head K, Webster KE, Dew J, Richmond P, Snelling T, Bhutta MF, Schilder AG, Burton MJ, Brennan-Jones CG. Cochrane Database Syst Rev. 2021 Feb 4; 2(2):CD013052. Epub 2021 Feb 4.
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