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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 111406-87-2
Drug Levels and Effects
Summary of Use during Lactation
No published information is available on the use of zileuton during breastfeeding; however, manufacturer's data indicate that the dose in milk is low. Because there is no published experience with zileuton during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Beclomethasone, Cromolyn, Montelukast, Terbutaline, Theophylline
Substance Identification
Substance Name
Zileuton
CAS Registry Number
111406-87-2
Drug Class
- Breast Feeding
- Anti-Asthmatic Agents
- Leukotriene Antagonists
- Lipoxygenase Inhibitors
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- PubChem SubstanceRelated PubChem Substances
- High ability of zileuton ((±)-1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea) to stimulate I(K(Ca)) but suppress I(K(DR)) and I(K(M)) independently of 5-lipoxygenase inhibition.[Eur J Pharmacol. 2020]High ability of zileuton ((±)-1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea) to stimulate I(K(Ca)) but suppress I(K(DR)) and I(K(M)) independently of 5-lipoxygenase inhibition.Hung TY, Huang CW, Wu SN. Eur J Pharmacol. 2020 Nov 15; 887:173482. Epub 2020 Aug 12.
- Review Zafirlukast.[Drugs and Lactation Database (...]Review Zafirlukast.. Drugs and Lactation Database (LactMed®). 2006
- Review The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor.[Int J Immunopharmacol. 1992]Review The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor.Bell RL, Young PR, Albert D, Lanni C, Summers JB, Brooks DW, Rubin P, Carter GW. Int J Immunopharmacol. 1992 Apr; 14(3):505-10.
- Kinetics and mechanism of degradation of Zileuton, a potent 5-lipoxygenase inhibitor.[Pharm Res. 1992]Kinetics and mechanism of degradation of Zileuton, a potent 5-lipoxygenase inhibitor.Alvarez FJ, Slade RT. Pharm Res. 1992 Nov; 9(11):1465-73.
- Review Diflunisal.[Drugs and Lactation Database (...]Review Diflunisal.. Drugs and Lactation Database (LactMed®). 2006
- Zileuton - Drugs and Lactation Database (LactMed®)Zileuton - Drugs and Lactation Database (LactMed®)
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