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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Drugs and Lactation Database (LactMed®) [Internet].

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Interferon Gamma-1b

Last Revision: October 15, 2023.

Estimated reading time: 1 minute

CASRN: 98059-61-1

Drug Levels and Effects

Summary of Use during Lactation

Interferon gamma is a normal component of human milk. No data are available on the use of exogenous interferon gamma 1b during breastfeeding. However, the amounts of the similar drugs, interferon alfa and interferon beta-1a, excreted into milk are very low. Any interferon in breastmilk is probably destroyed in the infant's gastrointestinal tract and not absorbed, except perhaps in neonates.

Drug Levels

Maternal Levels. Measurements of the colostrum 6 mothers of preterm infants found an average of 2 ng/L of interferon gamma; two mothers of full-term infants had an average of 2.2 ng/L. At over 30 days postpartum, milk of 3 mothers of preterm infants contained 2.6 ng/L of interferon gamma; the milk of 28 mothers of full-term infants contained an average of 0.7 ng/L.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Srivastava MD, Srivastava A, Brouhard B, et al. Cytokines in human milk. Res Commun Mol Pathol Pharmacol 1996;93:263-87. [PubMed: 8896040]

Substance Identification

Substance Name

Interferon Gamma-1b

CAS Registry Number


Drug Class

Breast Feeding


Milk, Human

Immunologic Adjuvants

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501465PMID: 30000525


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