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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

Cover of Drugs and Lactation Database (LactMed®)

Drugs and Lactation Database (LactMed®) [Internet].

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Last Revision: May 17, 2021.

Estimated reading time: 1 minute

CASRN: 144034-80-0

image 135110600 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Breastmilk levels of rizatriptan are low and the half-life in milk is relatively short. Amounts ingested by the infant are small and unlikely to affect the nursing infant.

Drug Levels

Maternal Levels. Five women who were at least 1 month postpartum and used rizatriptan to treat migraine provided one milk sample before their dose, then additional milk samples at 1, 2, 4, 8, 12 and 24 hours after their 10 mg oral dose. The average peak milk level was 58.4 mcg/L (range 14.6 to 105.6 mcg/L) and occurred 2 hours after the dose in 4 women ad 4 hours after the dose in another. The average milk level was 9 mcg/L (range 2.6 to 14.8 mcg/L) and the average half-life in milk was 2.2 hours (range 1.6 to 3.1 hours). The average daily infant dosage of rizatriptan was 1.3 mcg/kg (range 0.4 to 2.2 mcg/kg) and the weight-adjusted infant dosage averaged 0.9% (range 0.5 to 1.4%) of the maternal dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Eletriptan, Sumatriptan, Zolmitriptan


Amundsen S, Nordeng H, Fuskevåg OM, et al. Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding. Basic Clin Pharmacol Toxicol. 2021;128:795–804. [PubMed: 33730376]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Serotonin Receptor Agonists

Serotonin 5-HT1 Receptor Agonists


Vasoconstrictor Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501462PMID: 30000522


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